Details of the Drug Combinations

General Information of This Drug (ID: DMR2IQ4)

Drug Name

Tizanidine DMR2IQ4

Synonyms

Sirdalud; Ternelin; Tizanidina; Tizanidinum; Sirdalud (TN); Tizanidina [INN-Spanish]; Tizanidine (INN); Tizanidine [INN:BAN]; Tizanidinum [INN-Latin]; Zanaflex (TN); 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole; 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole; 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine

Indication

Disease Entry	ICD 11	Status	REF
Spasm	MB47.3	Approved	[1]
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Therapeutic Class

Analgesics

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Vemurafenib + Tizanidine	DCNYWZJ	Vemurafenib	Malignant Melanoma, Neoplasms	[2]
Ibuprofen + Tizanidine	DCZ2VS8	Ibuprofen	Low Back Pain	[3]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7308).
2	ClinicalTrials.gov (NCT01844674) A Study on the Effect of Vemurafenib on the Pharmacokinetics of a Single Dose of Tizanidine in Patients With BRAFV600 Mutation-Positive Metastatic Malignancies
3	ClinicalTrials.gov (NCT03068897) Ibuprofen Plus Metaxolone, Tizanidine, or Baclofen for Low Back Pain