Details of the Drug Combinations

General Information of This Drug (ID: DMR9PCT)

Drug Name
VX-970   DMR9PCT
Synonyms VE 822
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

5 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Gemcitabine + VX-970 DCP8VKF Gemcitabine Advanced Solid Tumor [2]
Irinotecan + VX-970 DC9713L Irinotecan Advanced Solid Tumor [2]
Topotecan + VX-970 DCQ5WST Topotecan Carcinoma, Non-Small -Cell Lung [3]
VX-970 + Midazolam DCF3FEQ Midazolam Pain [4]
Irinotecan + VX-970 DCPZ5BW Irinotecan Clinical Stage III Gastric Cancer AJCC v8 [5]
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References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT02157792) M6620 First in Human Study
3 ClinicalTrials.gov (NCT02487095) Trial of Topotecan With VX-970 (M6620), an ATR Kinase Inhibitor, in Small Cell Cancers and Extrapulmonary Small Cell Cancers
4 ClinicalTrials.gov (NCT05866055) A Phase 1 Dose Escalation Study of VX-973 in Healthy Adults
5 ClinicalTrials.gov (NCT03641313) Berzosertib and Irinotecan in Treating Patients With Progressive, Metastatic, or Unresectable TP53 Mutant Gastric or Gastroesophageal Junction Cancer