Details of the Drug Combinations

General Information of This Drug (ID: DMRJFN9)

Drug Name

Theophylline DMRJFN9

Synonyms

Bronchoretard; Cetraphylline; Chronophyllin; Dimethylxanthine; Elixophylline; Liquophylline; Pseudotheophylline; Afonilum Retard; Bronchodid Duracap; Elixophyllin SR; Somophyllin CRT; Spophyllin retard; Telbans DrySyrup; Teofilina [Polish]; Theal tablets; Theobid Duracap; Theodur Dry Syrup; Uniphyllin continus; Elixophyllin (TN); Elixophyllin(e); Pulmo-Timelets; Somophyllin-CRT; Somophyllin-DF; Theo-Organidin; Theoclear-200; Theodur G (TN); Theolair (TN); Theophylline (JP15); Theophylline-SR; Quibron-t (TN); Theo-Dur-Sprinkle; Theophylline-[8-3H; Theoclear L.A.-130; 1,3 Dimethylxanthine; 1,3-Dimethylxanthine; 1H-purine-2,6-dione

Indication

Disease Entry	ICD 11	Status	REF
Bronchitis	CA20	Approved	[1]
Chronic obstructive pulmonary disease	CA22	Approved	[2]
Lung cancer	2C25.0	Approved	[1]
Non-small-cell lung cancer	2C25.Y	Approved	[1]
Pulmonary disease	1B10-1F85	Approved	[1]
Pulmonary emphysema	CA21.Z	Approved	[1]
Severe asthma	CA23	Approved	[1]
Asthma	CA23	Investigative	[1]
------------------------------------------------------------------------------------


⏷ Show the Full List of Indication(s)

Therapeutic Class

Bronchodilator Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

56 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Theophylline	DCJIZCE	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Albendazole + Theophylline	DC9MJ5C	Albendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Artemisinin + Theophylline	DCBP8IA	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BIO-300 + Theophylline	DC3J8HM	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Theophylline	DCBUGM9	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cefmenoxime + Theophylline	DC981WL	Cefmenoxime	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Theophylline	DCYJ5IQ	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chlorzoxazone + Theophylline	DCCFYH3	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cytarabine + Theophylline	DCN2AFM	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Docetaxel + Theophylline	DCVIY8A	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Doxorubicin + Theophylline	DCEC0FA	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Epinephrine + Theophylline	DC0LKRR	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Hyodeoxycholic acid + Theophylline	DC2DKXU	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Imatinib + Theophylline	DCNU9RF	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Loperamide + Theophylline	DCKCPEL	Loperamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maprotiline + Theophylline	DCTZCDU	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maraviroc + Theophylline	DC4T1RA	Maraviroc	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mycophenolic acid + Theophylline	DCZ3SPM	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Theophylline	DCQ40G4	Probenecid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pyrazinamide + Theophylline	DC2U92O	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
SCH 727965 + Theophylline	DCXLKYH	SCH 727965	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sivelestat + Theophylline	DCO3ISG	Sivelestat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tamoxifen + Theophylline	DC9GSM8	Tamoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Testosterone cypionate + Theophylline	DCFFJG4	Testosterone cypionate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Gefitinib	DCT43CP	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + PMID28460551-Compound-2	DCT8F1G	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Miglustat	DCMR7TH	Miglustat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + BHV-0223	DC9WL6Z	BHV-0223	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Phenprocoumon	DCFIY0C	Phenprocoumon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Pazopanib	DCTXXWM	Pazopanib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Procarbazine	DCSO885	Procarbazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Eflornithine	DCOF40E	Eflornithine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + PF-02545920	DCNKG0V	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Lubiprostone	DC85KNG	Lubiprostone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Oseltamivir	DC947T8	Oseltamivir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Methocarbamol	DCY7P4L	Methocarbamol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Bortezomib	DCLPNJ5	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Clascoterone	DCPJLZQ	Clascoterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Trimethobenzamide	DCP6FW8	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Maprotiline	DCGFRP9	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Leflunomide	DCOUH2W	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Novobiocin	DCX42K4	Novobiocin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Brincidofovir	DC4HO6G	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Valproic Acid	DCACQKZ	Valproic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Mefloquine	DCXI7BY	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Pizotyline	DCXA7WZ	Pizotyline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Lacosamide	DCTMMK7	Lacosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Zileuton	DCEAA08	Zileuton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Testolactone	DCGY17F	Testolactone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Auranofin	DC4SJV8	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tolazoline + Theophylline	DCY0NSS	Tolazoline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Topotecan + Theophylline	DCFNGTV	Topotecan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Trihexyphenidyl + Theophylline	DCGDANU	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Vorinostat + Theophylline	DCBSXYM	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
VR-776 + Theophylline	DCEW4F8	VR-776	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zaleplon + Theophylline	DCX1TCQ	Zaleplon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
------------------------------------------------------------------------------------


⏷ Show the Full List of 56 DrugCom(s)

8 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Budesonide + Theophylline	DC5BCNZ	Budesonide	Chronic Obstructive Pulmonary Disease	[5]
Doxapram + Theophylline	DCPXHXW	Doxapram	Weaning Failure	[6]
Edivoxetine + Theophylline	DCBOG3F	Edivoxetine	Major Depressive Disorder	[7]
Erlotinib + Theophylline	DCLIF0U	Erlotinib	Non-small Cell Lung Cancer	[8]
Theophylline + Quinine	DC45DY7	Quinine	Pharmacokinetics	[9]
Theophylline + Colchicine	DCIQ6O7	Colchicine	Pharmacokinetics	[10]
Roflumilast + Theophylline	DCF422P	Roflumilast	COPD	[11]
Theophylline + Cortisone	DCQ0CDC	Cortisone	Chronic Obstructive Pulmonary Disease	[12]
------------------------------------------------------------------------------------


⏷ Show the Full List of 8 DrugCom(s)

References

1	Theophylline FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 413).
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5	ClinicalTrials.gov (NCT00634413) Effect of ADC4022 Co-Administered With Budesonide on Pulmonary Inflammation in Subjects With Moderate to Severe COPD
6	ClinicalTrials.gov (NCT03894189) The Effect of Doxapram Versus Theophylline on Diaphragmatic Function
7	ClinicalTrials.gov (NCT01263106) A Study of LY2216684 and Theophylline in Healthy Subjects
8	ClinicalTrials.gov (NCT02080078) A Phase I Dose Escalation Study of Erlotinib in Combination With Theophylline
9	ClinicalTrials.gov (NCT00779259) Drug - Drug Interaction Study Between Quinine Sulfate and Theophylline
10	ClinicalTrials.gov (NCT00983905) Drug-Drug Interaction Study of Colchicine and Theophylline
11	ClinicalTrials.gov (NCT02340520) Enhancement of Corticosteroid Efficacy in COPD
12	ClinicalTrials.gov (NCT02261727) Theophylline and Steroids in Chronic Obstructive Pulmonary Disease (COPD) Study