Details of the Drug Combinations

General Information of This Drug (ID: DMS3YE9)

• Drug Name: Amantadine (DMS3YE9)
• Synonyms: Adamantamine; Adamantanamine; Adamantylamine; Amant; Amantadina; Amantadinum; Amantidine; Aminoadamantane; Endantadine; Mantadine; Symadine; Wiregyt; Amantadine Base; BIA4304; OR14310; Amantadina [INN-Spanish]; Amantadine (INN); Amantadine [INN:BAN]; Amantadinum [INN-Latin]; Gen-Amantadine; Pk-merz; Symmetrel (TN); TCMDC-125869; ADAMANTANE,1-AMINO; Adamantan-1-amine; Adamantan-1-ylamine; Tricyclo[3.3.1.1^3,7]decan-1-amine; Tricyclo(3.3.1.13,7)decan-1-amine; Tricyclo[3.3.1.1(3,7)]decan-1-amine; Tricyclo[3.3.1.1(3,7)]decan-1-ylamine; Tricyclo[3.3.1.1(3,7)]decane-1-amine; Tricyclo[3.3.1.1(sup3,7)]decan-1-amine; Tricyclo(3.3.1.1(sup 3,7))decan-1-amine; Tricyclo(3.3.1.1(sup 3.7))decan-1-amine; Tricyclo[3.3.1.1~3,7~]decan-1-amine; Tricyclo(3.3.1.1(3,7))-decan-1-amine; 1-Adamantamine; 1-Adamantanamine; 1-Adamantanamine (8CI); 1-Adamantylamine; 1-Aminoadamantane; 1-Aminotricyclo(3.3.1.1(sup 3,7))decane

Indication

Influenza A virus infection; ICD 11: 1E30; Status: Approved [1]; Parkinsonian disorder; ICD 11: N.A.; Status: Approved [2]; Postencephalitic Parkinson disease; ICD 11: N.A.; Status: Approved [2]

• Therapeutic Class: Antiviral Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

48 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Allopurinol + Amantadine	DCFQT69	Allopurinol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + Gefitinib	DCGI57M	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + Fomepizole	DCVZCQY	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + Dexmedetomidine	DCKFLYZ	Dexmedetomidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + IT-141	DCAC5OH	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + Methylergonovine	DCLCL85	Methylergonovine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + Testosterone cypionate	DCJXS11	Testosterone cypionate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + Naringenin	DC80B3H	Naringenin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + Arfolitixorin	DCVENAY	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + Tiagabine	DCPMXOU	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + GINKGOLIDE A	DCVRNMW	GINKGOLIDE A	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + BRL-15572	DC6TARN	BRL-15572	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + Bortezomib	DCE0K1P	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + Mycophenolic acid	DCS7HNE	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + Mefloquine	DCU29G9	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + Olmesartan medoxomil	DC7NDTZ	Olmesartan medoxomil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + Auranofin	DCS7RA4	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + Vorinostat	DCXDCJN	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Amantadine	DC0YU7X	Amiloride	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Armodafinil + Amantadine	DCHFH3R	Armodafinil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Azatadine + Amantadine	DCS3NAS	Azatadine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BHV-0223 + Amantadine	DCSZXIT	BHV-0223	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Amantadine	DC1JCGB	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Busulfan + Amantadine	DC89QEN	Busulfan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Amantadine	DCGAC3Q	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Crotamiton + Amantadine	DCBOUAE	Crotamiton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cytarabine + Amantadine	DC2NV7M	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diazoxide + Amantadine	DCWYTEM	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Docetaxel + Amantadine	DCIXFL3	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Doxorubicin + Amantadine	DC1CQY2	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fluspirilene + Amantadine	DCY1TS0	Fluspirilene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Imatinib + Amantadine	DCILVC4	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Leflunomide + Amantadine	DC087IQ	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maprotiline + Amantadine	DCLBM65	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methocarbamol + Amantadine	DCPBUW6	Methocarbamol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Metyrosine + Amantadine	DCO8UKI	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Amantadine	DC4RNQ8	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pentamidine + Amantadine	DCUC0VT	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phensuximide + Amantadine	DC41COW	Phensuximide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pinacidil + Amantadine	DCFWHNG	Pinacidil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PMID28460551-Compound-2 + Amantadine	DCD9MYA	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Primidone + Amantadine	DCP7GTX	Primidone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pyrazinamide + Amantadine	DCEXR7C	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Quinine + Amantadine	DCXRX2F	Quinine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ribavirin-TP + Amantadine	DC8V5TL	Ribavirin-TP	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Topotecan + Amantadine	DCGPFG8	Topotecan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Vinblastine + Amantadine	DCSKNRF	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zaleplon + Amantadine	DCMLZ5G	Zaleplon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Propranolol + Amantadine	DCRITW0	Propranolol	Cocaine-Related Disorders	[5]
Topiramate + Amantadine	DCBAE1L	Topiramate	Idiopathic Parkinson's Disease	[6]
Topiramate + Amantadine	DCH1826	Topiramate	Parkinson's Disease	[7]
Citicoline + Amantadine	DC9NQED	Citicoline	Intensive Care Unit	[8]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4128).
• [2] Amantadine FDA Label
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [5] ClinicalTrials.gov (NCT00158132) Effectiveness of Amantadine and Propranolol for Treating Cocaine Dependence - 2
• [6] ClinicalTrials.gov (NCT01789047) Topiramate as an Adjunct to Amantadine in the Treatment of Dyskinesia in Parkinson's Disease
• [7] ClinicalTrials.gov (NCT00794313) Quantification of the Antidyskinetic Effect of Amantadine and Topiramate in Parkinson's Disease
• [8] ClinicalTrials.gov (NCT03430817) Citicholine-Amantadine Trial in Traumatic Brain Injury