General Information of This Drug (ID: DMSC4A7)

Drug Name
Indomethacin   DMSC4A7
Synonyms
Aconip; Amuno; Arthrexin; Artracin; Artrinovo; Artrivia; Bonidin; Bonidon; Catlep; Confortid; Dolcidium; Dolovin; Durametacin; Elmetacin; Hicin; IMN; Idomethine; Imbrilon; Inacid; Indacin; Indameth; Indmethacine; Indocid; Indocin; Indomecol; Indomed; Indomee; Indometacin; Indometacina; Indometacine; Indometacinum; Indometacyna; Indomethacine; Indomethacinum; Indomethancin; Indomethazine; Indomethegan; Indomethine; Indometicina; Indomo; Indomod; Indoptic; Indoptol; Indorektal; Indoxen; Inflazon; Infrocin; Lausit; Liometacen; Metacen; Metartril; Methazine; Metindol; Mezolin; Miametan; Mikametan; Mobilan; Novomethacin; Reumacide; Sadoreum; Tannex; Vonum; Bonidon Gel; DESMETHYL INDOMETHACIN; Dolcidium PL;Flexin continus; Indocid Pda; Indocid Sr; Indocin Sr; Indolar SR; Indometacyna [Polish]; Indometicina [Spanish]; Inteban sp; Rhemacin LA; Rheumacin LA; I 7378; IN1454; Indomet 140; Aconip (TN); Apo-Indomethacin; Chibro-amuno; Chrono-indicid; Chrono-indocid; Indo-Lemmon; Indo-Spray; Indo-phlogont; Indo-rectolmin; Indo-tablinen; Indocid (TN); Indocid (pharmaceutical); Indocin (TN); Indocin I.V; Indometacina [INN-Spanish]; Indometacine [INN-French]; Indometacinum [INN-Latin]; Indomethacin (USP); Indomethacin [USAN:BAN]; Novo-Methacin; Indochron E-R (TN); Indocin I.V.; Indocin-SR (TN); Indometacin (JP15/INN); Indomethacin & MAP-30; Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin, Indomethacin
Indication
Disease Entry ICD 11 Status REF
Bursitis N.A. Approved [1]
Gout FA25 Approved [1]
Osteoarthritis FA00-FA05 Approved [1]
Patent ductus arteriosus N.A. Approved [1]
Rheumatic disorder N.A. Approved [1]
Rheumatoid arthritis FA20 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 1/2 [3]
Synovitis N.A. Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Antiinflammatory Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Indomethacin + Idarubicin DCTVNM7 Idarubicin Glioblastoma? (Cell Line: T98G) [4]
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8 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Acetaminophen + Indomethacin DCH27IG Acetaminophen Patent Ductus Arteriosus [5]
Enzalutamide + Indomethacin DCZ64FA Enzalutamide Metastatic Prostate Carcinoma [6]
Epinephrine + Indomethacin DCTPM8K Epinephrine Post-ERCP Acute Pancreatitis [7]
GFT-505 + Indomethacin DCA1XJU GFT-505 Drug-drug Interaction [8]
Ibuprofen + Indomethacin DCSCRMD Ibuprofen Patent Ductus Arteriosus [9]
Lesinurad + Indomethacin DCY25NE Lesinurad Gout [10]
Indomethacin + Tacrolimus DCWGHF4 Tacrolimus Post-ERCP Acute Pancreatitis [11]
Nifedipine + Indomethacin DCCXUIM Nifedipine Preterm Labor [12]
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⏷ Show the Full List of 8 DrugCom(s)

References

1 Indomethacin FDA Label
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 ClinicalTrials.gov (NCT04344457) Evaluate the Efficacy and Safety of Oral Hydroxychloroquine, Indomethacin and Zithromax in Subjects With Mild Symptoms of COVID-19. U.S. National Institutes of Health.
4 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5 ClinicalTrials.gov (NCT03648437) Paracetamol And Ibuprofen/Indomethacin in Closing Patent Ductus Arteriosus
6 ClinicalTrials.gov (NCT02935205) Enzalutamide and Indomethacin in Treating Patients With Recurrent or Metastatic Hormone-Resistant Prostate Cancer
7 ClinicalTrials.gov (NCT02116309) Randomized Trial of Rectal Indomethacin and Papillary Spray of Epinephrine Versus Rectal Indomethacin to Prevent Post-ERCP Pancreatitis
8 ClinicalTrials.gov (NCT03985969) Study to Investigate the Potential Drug-Drug Interaction Between Elafibranor and Indomethacin
9 ClinicalTrials.gov (NCT02884219) Early Treatment Versus Expectative Management of PDA in Preterm Infants
10 ClinicalTrials.gov (NCT01884272) NSAID Drug Interaction Study
11 ClinicalTrials.gov (NCT05252754) Rectal Indomethacin and Oral Tacrolimus Versus Combination to Prevent Post-ERCP Pancreatitis
12 ClinicalTrials.gov (NCT02438371) Nifedipine or Nifedipine Plus Indomethacin for Treatment of Acute Preterm Labor