Details of the Drug Combinations

General Information of This Drug (ID: DMSIMD8)

• Drug Name: Cefuroxime (DMSIMD8)
• Synonyms: Anaptivan; Biociclin; Biofuroksym; Bioxima; CXM; Cefofix; Cefumax; Cefurex; Cefuril; Cefuroxim; Cefuroximesodium; Cefuroximine; Cefuroximo; Cefuroximum; Cephuroxime; Cetroxil; Colifossim; Curocef; Curoxim; Curoxima; Curoxime; Froxal; Furoxil; Kesint; Ketocef; Lifurox; Medoxim; Sharox; Spectrazolr; Ultroxim; Zinacef;CEFUROXIME AND DEXTROSE IN DUPLEX CONTAINER; CEFUROXIME SODIUM; Cefuroxim AJ; Cefuroxim Fresenius; Cefuroxim Genericsn; Cefuroxim Hexal; Cefuroxim Lilly; Cefuroxim MN; Cefuroxim Norcox; Cefuroxim curasan; Cefuroxima Fabra; Cefuroxima Richet; Cefuroxime for Injection and Dextrose for Injection in Duplex Container; Cefuroxime na; Cefuroxime sodium salt; KEFUROX IN PLASTIC CONTAINER; Sodium cefuroxime; ZINACEF IN PLASTIC CONTAINER; Zinacef Danmark; Ceftin (TN); Cefuroxim Norcox [inj.]; Cefuroxime (TN); Cefuroximo [INN-Spanish]; Cefuroximum [INN-Latin]; Cetroxil [inj.]; Froxal [inj.]; KS-1040; Sharox [inj.]; Zinacef (TN); Zinnat (TN); Zinnat [inj.]; Cefuroxime (USAN/INN); Cefuroxime [USAN:INN:BAN]; Cefuroxime sodium (JP15/USP); Cefuroxime sodium [USAN:BAN:JAN]; Sodium (6R-(6alpha,7beta(Z)))-3-(((aminocarbonyl)oxy)methyl)-7-(2-furyl(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate; Sodium (6R,7R)-7-(2-(2-furyl)glyoxylamido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate, 7(sup 2)-(Z)-(O-methyloxime), carbamate (ester); (6R,7R)-3-(carbamoyloxymethyl)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-3-[(carbamoyloxy)methyl]-7-[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2Z)-2-furan-2-yl-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-(2-(2-Furyl)glyoxylamido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid 7(sup 2)-(Z)-(O-methyloxime) carbamate (ester); 3-[(carbamoyloxy)methyl]-7beta-[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido]-3,4-didehydrocepham-4-carboxylic acid

Indication

Acute bronchiolitis; ICD 11: N.A.; Status: Approved [1]; Acute bronchitis; ICD 11: CA42; Status: Approved [2]; Acute gonococcal cervicitis; ICD 11: N.A.; Status: Approved [1]; Acute maxillary sinusitis; ICD 11: N.A.; Status: Approved [1]; Acute otitis media; ICD 11: AB00; Status: Approved [1]; Bacteremia; ICD 11: 1A73; Status: Approved [1]; Staphylococcal pneumonia; ICD 11: N.A.; Status: Approved [1]; Staphylococcus aureus infection; ICD 11: N.A.; Status: Approved [1]; Sinusitis; ICD 11: CA0A.Z; Status: Investigative [1]

• Therapeutic Class: Antibiotics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Amikacin + Cefuroxime	DCZ9MQJ	Amikacin	Sepsis	[3]
Levofloxacin + Cefuroxime	DC10G6Q	Levofloxacin	Complication of Surgical Procedure	[4]
Nitrofurantoin + Cefuroxime	DC6DRHP	Nitrofurantoin	Complication of Surgical Procedure	[4]
Cefuroxime + Metronidazole	DCC5QVQ	Metronidazole	Pancreatic Cancer	[5]

References

• [1] Cefuroxime FDA Label
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [3] ClinicalTrials.gov (NCT04470973) Pharmacokinetics of Amikacin and Cefuroxime in Critically Ill Patients.
• [4] ClinicalTrials.gov (NCT02789579) The Preventive Infection Role of One Week Antibiotics Before Minimally Invasive Upper Tract Lithotomy
• [5] ClinicalTrials.gov (NCT05784311) Standard Versus Prolonged Antibiotic Prophylaxis After Pancreatoduodenectomy (SPARROW)