Details of the Drug Combinations

General Information of This Drug (ID: DMSQZE2)

Drug Name
Asenapine   DMSQZE2
Synonyms
Asenapi; Asenapine [INN:BAN]; Saphris (TN); [13C,2H3]-Asenipine; Trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole; 1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-met; 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3-6,7)oxepino(4,5-c)pyrrole
Indication
Disease Entry ICD 11 Status REF
Schizophrenia 6A20 Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

104 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Asenapine DCB16FS Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acetohydroxamic Acid + Asenapine DC1VU0E Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Aciclovir + Asenapine DCJJXPY Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Anamorelin + Asenapine DC7RJXC Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Arfolitixorin + Asenapine DC7DUMN Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Aprepitant DCADRQL Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Meclofenamic acid DCIM2WL Meclofenamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Mebutamate DCLPA9O Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Bepridil DCSJBLB Bepridil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Gefitinib DCQAWBS Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Diethylcarbamazine DCP4FFM Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Epinephrine DC4VUTY Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + PMID28460551-Compound-2 DCM1XVZ PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Vinblastine DCYDRE9 Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Sivelestat DC42KUB Sivelestat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Anamorelin DCCOTL2 Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Fomepizole DCND23J Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Triapine DCIUQGZ Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Acitretin DCXO6QN Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Everolimus DC3ZV8K Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Rifampin DCLB24N Rifampin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + IT-141 DCXMF84 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Methylergonovine DCA0PF3 Methylergonovine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Buspirone DCEIIZY Buspirone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Efavirenz DCWZKT9 Efavirenz Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Guanfacine DCT3K8S Guanfacine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + SCH 727965 DCISG7Q SCH 727965 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Emetine DC8T8AO Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Carglumic acid DCWJKO5 Carglumic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Memantine DCPE3AA Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Methoxsalen DCCKI64 Methoxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Pazopanib DC0YLU5 Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Ciprofibrate DCGWKXX Ciprofibrate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Pentamidine DCRMZPI Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + BIO-300 DC0R15N BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Trazodone DCD1WL1 Trazodone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + GINKGOLIDE A DCF55PO GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Diazoxide DCL6ZP2 Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Fenoprofen DCTV7NO Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Entacapone DCGZ8SU Entacapone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Allopurinol DCGGE07 Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Idarubicin DCL1W3T Idarubicin Glioblastoma? (Cell Line: T98G) [2]
Asenapine + Darunavir DC3IF0L Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Bortezomib DCZIFHG Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Methylene blue DC6Z2MH Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Mesalazine DCR2G2D Mesalazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Topotecan DCGKD9U Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Clascoterone DC08RN2 Clascoterone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Maprotiline DCH63UP Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Oxyphenbutazone DCC1W7T Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Teriflunomide DC95YEL Teriflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Ethambutol DCJL43P Ethambutol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Brincidofovir DC600NT Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Quinine DCE84L4 Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Endoxifen DCQV5F5 Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Mycophenolic acid DCHL4MS Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Mefloquine DCOJT4E Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Doxorubicin DCL8LNK Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Auranofin DC4ZK74 Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Cerivastatin DC98I8G Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Enoxacin DCV85TU Enoxacin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Cytarabine DCN6LYP Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Azatadine + Asenapine DCHOFPA Azatadine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BIO-300 + Asenapine DCSBG7P BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bortezomib + Asenapine DCVFPWW Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Asenapine DC46UH7 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Buspirone + Asenapine DCFB7E1 Buspirone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Asenapine DCGC3IK Cevimeline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chlorzoxazone + Asenapine DCI3ZD2 Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cisatracurium + Asenapine DCUMND8 Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Clindamycin + Asenapine DC6ZW9E Clindamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + Asenapine DCCSZVP Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dantrolene + Asenapine DCHIKQ9 Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diethylcarbamazine + Asenapine DC3EPJO Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Eflornithine + Asenapine DCSV3DR Eflornithine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Asenapine DC553E1 Entacapone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ezetimibe + Asenapine DCC9AMB Ezetimibe Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
FORMESTANE + Asenapine DC2BYZJ FORMESTANE Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Asenapine DCIHHIK Ibutilide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Leflunomide + Asenapine DC4Z4DS Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Levamisole + Asenapine DCILJUX Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
LY03004 + Asenapine DCPTHQQ LY03004 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + Asenapine DCQLN5M Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mefloquine + Asenapine DC8XGER Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + Asenapine DCXC21Z Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Miglustat + Asenapine DCU1RD6 Miglustat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Moricizine + Asenapine DCAYZ69 Moricizine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mycophenolic acid + Asenapine DCBWJSJ Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nabilone + Asenapine DCQTIWA Nabilone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Asenapine DC9IJ5G Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Asenapine DC3BPF6 Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PMID28460551-Compound-2 + Asenapine DCN5I91 PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Probenecid + Asenapine DCZ528W Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pyrazinamide + Asenapine DCLNE1Q Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
SCH 727965 + Asenapine DCPORRP SCH 727965 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Spironolactone + Asenapine DCZLURT Spironolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Terameprocol + Asenapine DC16PWQ Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tolvaptan + Asenapine DCYD4VJ Tolvaptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Topotecan + Asenapine DCP0NC2 Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tranexamic acid + Asenapine DCU6KZP Tranexamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trihexyphenidyl + Asenapine DC2188W Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trimethobenzamide + Asenapine DCQN7EW Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ursodeoxycholic acid + Asenapine DCIW2TM Ursodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vorinostat + Asenapine DC4996Y Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 104 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 22).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.