Details of the Drug Combinations

General Information of This Drug (ID: DMT2EJP)

Drug Name

Podofilox DMT2EJP

Synonyms

podophyllotoxin; 518-28-5; Condylox; Condyline; Wartec; Podophyllotoxin 7; Podophyllinic acid lactone; Warticon; (-)-Podophyllotoxin; Podofilox [USAN]; CCRIS 565; UNII-L36H50F353; Podophyllotoxin, 95%; HSDB 7238; NSC24818; CHEMBL61; EINECS 208-250-4; NSC 24818; (5R,5aR,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one; MLS000069495; AI3-50456; CHEBI:50305; Podofilox (USAN); L36H50F353; Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one,; Podophyllotoxin

Indication

Disease Entry	ICD 11	Status	REF
Condyloma	1A95	Approved	[1]
External genital and perianal wart	1A95	Approved	[1]
Verruca vulgaris	1E80	Approved	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

9 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
ABT-263 + Podofilox	DC8N4LC	ABT-263	Glioblastoma (Cell Line: JHH-136)	[2]
AZD8055 + Podofilox	DCHG9OK	AZD8055	Glioblastoma (Cell Line: JHH-136)	[3]
GDC0941 + Podofilox	DCJAOK9	GDC0941	Glioblastoma (Cell Line: JHH-136)	[3]
Plinabulin + Podofilox	DC8NJXE	Plinabulin	Glioblastoma (Cell Line: JHH-136)	[3]
Podofilox + Ruxolitinib	DCNWSTB	Ruxolitinib	T-cell leukemia/lymphoma (Cell Line: ED-40515)	[3]
Podofilox + Panobinostat	DCBCO1T	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Podofilox + Mitomycin	DC41WDV	Mitomycin	Diffuse large B cell lymphoma (Cell Line: TMD8)	[3]
Podofilox + Ruxolitinib	DCS5PVC	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[2]
Topetecan + Podofilox	DCGRKOC	Topetecan	Glioblastoma (Cell Line: JHH-136)	[3]
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⏷ Show the Full List of 9 DrugCom(s)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.