Details of the Drug Combinations

General Information of This Drug (ID: DMTK4LS)

Drug Name

Triptorelin DMTK4LS

Synonyms

Gonapeptyl depot (TN)

Indication

Disease Entry	ICD 11	Status	REF
Infertility	GB04	Approved	[1]
Solid tumour/cancer	2A00-2F9Z	Approved	[2]
Prostate cancer	2C82.0	Phase 4	[3]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Flutamide + Triptorelin	DC28TAD	Flutamide	Prostate Cancer	[4]
Letrozole + Triptorelin	DCU5C0O	Letrozole	Breast Cancer	[5]
Anastrozole + Triptorelin	DC4AK7R	Anastrozole	Breast Cancer	[6]
Letrozole + Triptorelin	DCM2F0J	Letrozole	Breast Cancer Invasive Nos	[7]
RAD-1901 + Triptorelin	DCMT3F2	RAD-1901	Breast Cancer	[8]
Cyproterone acetate + Triptorelin	DCGA62Z	Cyproterone acetate	Gender Dysphoria	[9]
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⏷ Show the Full List of 6 DrugCom(s)

References

1	Triptorelin FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1177).
3	ClinicalTrials.gov (NCT00633347) Use of Antagonist Versus Agonist GnRH in Oocyte Recipient Endometrium Preparation. U.S. National Institutes of Health.
4	ClinicalTrials.gov (NCT00104741) Triptorelin, Flutamide, and External-Beam Radiation Therapy or External-Beam Radiation Therapy Alone in Treating Patients With Stage II or Stage III Prostate Cancer
5	ClinicalTrials.gov (NCT00412022) HOBOE: A Phase 3 Study of Adjuvant Triptorelin and Tamoxifen, Letrozole, or Letrozole and Zoledronic Acid in Premenopausal Patients With Breast Cancer.
6	ClinicalTrials.gov (NCT05896566) A Window-of-Opportunity Trial of Giredestrant +/- Triptorelin vs. Anastrozole + Triptorelin in Premenopausal Patients With ER-positive/HER2-negative Early Breast Cancer
7	ClinicalTrials.gov (NCT02005887) TRial on the Endocrine Activity of Neoadjuvant Degarelix
8	ClinicalTrials.gov (NCT05982093) Elacestrant With/Without Triptorelin in Premenopausal Women With Luminal Breast Cancer
9	ClinicalTrials.gov (NCT02715232) Effects of Sex Steroids on the Serotonin System