Details of the Drug Combinations

General Information of This Drug (ID: DMTPRBX)

Drug Name

CGI-1316 DMTPRBX

Synonyms

CGI-1746; CGI-2233; CGI-2815; CGI-3130; CGI-560; CGI-676; Btk inhibitors (autoimmune disease/inflammatory disease); Btk inhibitors (autoimmune disease/inflammatory disease), CGI Pharmaceuticals; Btk inhibitors (autoimmune disease/inflammatory disease), Cellular Genomics; Btk inhibitors (autoimmune disease/inflammatory disease), Gilead

Indication

Disease Entry	ICD 11	Status	REF
Autoimmune diabetes	5A10	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
CGI-1316 + Ruxolitinib	DCPHVLL	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[2]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8066).
2	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.