Details of the Drug Combinations

General Information of This Drug (ID: DMTQ1Y3)

Drug Name
AXL-1717   DMTQ1Y3
Synonyms BVT-51004; IGF-1 inhibitors, Axelar/Biovitrum; IGF-1 inhibitors, Karolinska/Biovitrum; Insulin-like growth factor 1 inhibitors, Axelar/Biovitrum
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

19 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
AXL-1717 + GSK461364 DC8YXDF GSK461364 Ewing sarcoma (Cell Line: TC-71) [2]
AXL-1717 + Buparlisib DCDDOO6 Buparlisib Ewing sarcoma (Cell Line: TC-71) [2]
AXL-1717 + Ombrabulin DC9XLOP Ombrabulin Ewing sarcoma (Cell Line: TC-71) [2]
AXL-1717 + MK-1775 DCO6YJ1 MK-1775 Ewing sarcoma (Cell Line: TC-71) [2]
AXL-1717 + Artemether DC7PM0M Artemether Ewing sarcoma (Cell Line: TC-71) [2]
AXL-1717 + Panobinostat DCGAQXE Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
AXL-1717 + Steroid derivative 1 DCL1B7G Steroid derivative 1 Ewing sarcoma (Cell Line: TC-71) [2]
AXL-1717 + AT7519 DCFZRDC AT7519 Ewing sarcoma (Cell Line: TC-71) [2]
AXL-1717 + OSI-906 DCCF3FM OSI-906 Ewing sarcoma (Cell Line: TC-71) [2]
AXL-1717 + Cabozantinib DCXBF4X Cabozantinib Ewing sarcoma (Cell Line: TC-71) [2]
AXL-1717 + Tivantinib DC56PLM Tivantinib Ewing sarcoma (Cell Line: TC-71) [2]
AXL-1717 + Bardoxolone methyl DCVJNA8 Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [2]
AXL-1717 + Ruxolitinib DC5DW0G Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
AXL-1717 + PD-0325901 DCWUDI9 PD-0325901 Hodgkin lymphoma (Cell Line: U-HO1) [3]
AXL-1717 + Cabozantinib DC87RAR Cabozantinib Hodgkin lymphoma (Cell Line: U-HO1) [3]
AXL-1717 + Bardoxolone methyl DCQK90V Bardoxolone methyl Hodgkin lymphoma (Cell Line: U-HO1) [3]
Efaproxyn + AXL-1717 DCEHLB0 Efaproxyn Ewing sarcoma (Cell Line: TC-71) [2]
Verteporfin + AXL-1717 DCCOUD0 Verteporfin Ewing sarcoma (Cell Line: TC-71) [2]
Withaferin A + AXL-1717 DC6KW5I Withaferin A Ewing sarcoma (Cell Line: TC-71) [2]
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⏷ Show the Full List of 19 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7873).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.