Details of the Drug Combinations

General Information of This Drug (ID: DMTX8IZ)

Drug Name

Endoxifen DMTX8IZ

Synonyms

Endoxifen (topical formulation, cancer); Endoxifen (topical formulation, cancer), Jina Pharmaceuticals; Tamoxifen metabolite (topical formulation, cancer), Jina Pharmaceuticals

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Phase 2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

108 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Endoxifen	DCCRBKT	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Aminosalicylic acid + Endoxifen	DCYLZ83	Aminosalicylic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Anamorelin + Endoxifen	DC0T668	Anamorelin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Artemisinin + Endoxifen	DCQIRAC	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
AS-1949490 + Endoxifen	DC4E37A	AS-1949490	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Asenapine + Endoxifen	DCQV5F5	Asenapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Azatadine + Endoxifen	DCD79QN	Azatadine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Bosentan + Endoxifen	DC21UOZ	Bosentan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cerivastatin + Endoxifen	DC4951P	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Chlormezanone + Endoxifen	DCBN4XU	Chlormezanone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Chloroquine + Endoxifen	DCFVNMU	Chloroquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Chlorphenesin + Endoxifen	DCBCRFO	Chlorphenesin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Chlorzoxazone + Endoxifen	DCF9W2K	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Clindamycin + Endoxifen	DCKMNIT	Clindamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cytarabine + Endoxifen	DCOE7PP	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dactinomycin + Endoxifen	DCY67U3	Dactinomycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diazoxide + Endoxifen	DCOJQ72	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dihydroergotamine + Endoxifen	DC4GGQG	Dihydroergotamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Diphenidol + Endoxifen	DCL4DAL	Diphenidol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Docetaxel + Endoxifen	DCY4W67	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Dopamine + Endoxifen	DCFYYV2	Dopamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Doxorubicin + Endoxifen	DCNS6TN	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Eflornithine + Endoxifen	DCWT8GN	Eflornithine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Emetine + Endoxifen	DCB86YX	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Aprepitant	DCGOIR0	Aprepitant	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Bepridil	DCJWIS3	Bepridil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Primidone	DCFXRB2	Primidone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Gefitinib	DCTVZ1E	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Citalopram	DCTPF1S	Citalopram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Imipramine	DCRZQQI	Imipramine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Epinephrine	DCF9F7D	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + PMID28460551-Compound-2	DCIXBTO	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Mephenytoin	DCJHL9F	Mephenytoin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Fomepizole	DC83RF1	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Triapine	DCANA7B	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Rifampin	DCJIMIO	Rifampin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Methylergonovine	DCJZYTY	Methylergonovine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Isosorbide dinitrate	DCGGXLZ	Isosorbide dinitrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Metyrosine	DCQCVWN	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Efavirenz	DC42M8R	Efavirenz	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Testosterone cypionate	DCWIM6J	Testosterone cypionate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + K-134	DCQTK91	K-134	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Phensuximide	DC9F5L7	Phensuximide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + VR-776	DCAT8BC	VR-776	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Ciprofibrate	DCBF6I8	Ciprofibrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Naringenin	DC02I42	Naringenin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Clopidogrel	DCA4M35	Clopidogrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Triflupromazine	DC26RX8	Triflupromazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + BIO-300	DC8Z4AJ	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + PF-02545920	DCWG702	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Tiagabine	DCYT0NJ	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Ibutilide	DCY9NJL	Ibutilide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Benserazide	DCN3CSJ	Benserazide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Idarubicin	DCPVBNM	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + BRL-15572	DCIQWZD	BRL-15572	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Darunavir	DCDRZNV	Darunavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Bortezomib	DCHNTJD	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Moricizine	DCMN83G	Moricizine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Olanzapine	DCANA00	Olanzapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Cefmenoxime	DCYXER7	Cefmenoxime	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Trimethobenzamide	DCXMF1Q	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Maprotiline	DCT3VDJ	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Oxyphenbutazone	DCJIHAP	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Ethambutol	DC46FFO	Ethambutol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Leflunomide	DC3I0LP	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Chlorambucil	DCQJI1K	Chlorambucil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Bumetanide	DCIWPNO	Bumetanide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Brincidofovir	DCNHEE0	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Hyodeoxycholic acid	DC4MKSO	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Pomalidomide	DCH8JNI	Pomalidomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Mycophenolic acid	DCSPA4K	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Mefloquine	DC0IJ6C	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Lacosamide	DC1DCPH	Lacosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Iloprost	DC3U1TL	Iloprost	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Zileuton	DCMOBRR	Zileuton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Testolactone	DC70H1G	Testolactone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Auranofin	DCRLHPZ	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Aciclovir	DCIBYTV	Aciclovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Endoxifen + Acetohydroxamic Acid	DCBXD20	Acetohydroxamic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Estramustine + Endoxifen	DCLQ3XR	Estramustine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
ETHISTERONE + Endoxifen	DC4Z1UU	ETHISTERONE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Ezetimibe + Endoxifen	DCZHYFR	Ezetimibe	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Fenoprofen + Endoxifen	DCLL4W9	Fenoprofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Guanfacine + Endoxifen	DC0UIYC	Guanfacine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Hydralazine + Endoxifen	DCZ1SOC	Hydralazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
IT-141 + Endoxifen	DCHXSAY	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Kanamycin + Endoxifen	DC3MSHE	Kanamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Lacosamide + Endoxifen	DCFOTQ5	Lacosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Levamisole + Endoxifen	DCQ22XO	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Linagliptin + Endoxifen	DCV874B	Linagliptin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
LY03004 + Endoxifen	DCFIMP6	LY03004	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Maprotiline + Endoxifen	DCV0OOH	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Mebutamate + Endoxifen	DCW526A	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Memantine + Endoxifen	DCUCI3O	Memantine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Naltrexone + Endoxifen	DCO8NEF	Naltrexone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Niclosamide + Endoxifen	DCH1QRK	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Norcisapride + Endoxifen	DCR4TV4	Norcisapride	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Paromomycin + Endoxifen	DCSTHE3	Paromomycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Pazopanib HCl + Endoxifen	DCRTD2D	Pazopanib HCl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Pepstatin + Endoxifen	DC9ISLB	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Probenecid + Endoxifen	DCVE0XF	Probenecid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
SCH 727965 + Endoxifen	DCLVHUM	SCH 727965	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Spironolactone + Endoxifen	DC5L8PM	Spironolactone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Terameprocol + Endoxifen	DCM6RGO	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Testosterone + Endoxifen	DC1FKCS	Testosterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Triflupromazine + Endoxifen	DC9LV2H	Triflupromazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Ursodeoxycholic acid + Endoxifen	DCW4ST6	Ursodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Vorinostat + Endoxifen	DC760E6	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
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⏷ Show the Full List of 108 DrugCom(s)

References

1	ClinicalTrials.gov (NCT02311933) Tamoxifen Citrate or Z-Endoxifen Hydrochloride in Treating Patients With Locally Advanced or Metastatic, Estrogen Receptor-Positive, HER2-Negative Breast Cancer. U.S.National Institutes of Health.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.