Details of the Drug Combinations

General Information of This Drug (ID: DMUNJZB)

Drug Name

UCN-01 DMUNJZB

Synonyms

UCN; UCN01; Ucn 01; KRX-0601; KW-2401; UCN-02; (5s,6r,7r,9r,16r)-16-hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5h,14h-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one; 7-Hydroxystaurosporine; 7-hydroxystaurosporine (UCN-01)

Indication

Disease Entry	ICD 11	Status	REF
Non-small-cell lung cancer	2C25.Y	Phase 2	[1]
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Therapeutic Class

Anticancer Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
UCN-01 + Panobinostat	DCC6W2O	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
UCN-01 + Marizomib	DCX22K8	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
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4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Carboplatin + UCN-01	DCP28LT	Carboplatin	Unspecified Adult Solid Tumor, Protocol Specific	[3]
Irinotecan + UCN-01	DCK6OFW	Irinotecan	Advanced Adult Primary Liver Cancer	[4]
Topotecan + UCN-01	DCXOVQG	Topotecan	Fallopian Tube Cancer	[5]
UCN-01 + Perifosine	DCR4NGT	Perifosine	Accelerated Phase Chronic Myelogenous Leukemia	[6]
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References

1	ClinicalTrials.gov (NCT00082017) UCN-01 (7-Hydroxystaurosporine) to Treat Relapsed T-Cell Lymphomas. U.S. National Institutes of Health.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	ClinicalTrials.gov (NCT00036777) UCN-01 and Carboplatin in Treating Patients With Advanced Solid Tumors
4	ClinicalTrials.gov (NCT00031681) 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)
5	ClinicalTrials.gov (NCT00045175) UCN-01 and Topotecan in Treating Patients With Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cavity Cancer
6	ClinicalTrials.gov (NCT00301938) 7-Hydroxystaurosporine and Perifosine in Treating Patients With Relapsed or Refractory Acute Leukemia, Chronic Myelogenous Leukemia or High Risk Myelodysplastic Syndromes