Details of the Drug Combinations

General Information of This Drug (ID: DMV3UN4)

Drug Name

JTC-801 DMV3UN4

Synonyms

UNII-BXU45ZH6LI; BXU45ZH6LI; 244218-93-7; CHEMBL140979; N-(4-amino-2-methylquinolin-6-yl)-2-((4-ethylphenoxy)methyl)benzamide; N-(4-amino-2-methylquinolin-6-yl)-2-[(4-ethylphenoxy)methyl]benzamide; JTC-801 free base; AC1NSKGH; SCHEMBL4916443; GTPL1692; CHEBI:92314; MolPort-021-804-962; ZINC602902; BCPP000197; BDBM50094634; N-(4-amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]Benzamide; Benzamide, N-(4-amino-2-methyl-6-quinolinyl)-2-((4-ethylphenoxy)methyl)-; SB19531; BCP9000806; NCGC00161418-01; NCGC00161418-02

Indication

Disease Entry	ICD 11	Status	REF
Pain	MG30-MG3Z	Discontinued in Phase 2	[1]
------------------------------------------------------------------------------------

Therapeutic Class

Analgesics

Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

16 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Chloroquine + JTC-801	DCWH7VY	Chloroquine	DD2 (Cell Line: DD2)	[2]
Docetaxel + JTC-801	DCL04PL	Docetaxel	DD2 (Cell Line: DD2)	[2]
JTC-801 + Lumefantrine	DCENM97	Lumefantrine	DD2 (Cell Line: DD2)	[2]
JTC-801 + T-3.5	DC1EGRK	T-3.5	DD2 (Cell Line: DD2)	[2]
JTC-801 + T-3.5	DC49GJH	T-3.5	Hepatoblastoma (Cell Line: HB3)	[2]
JTC-801 + Verapamil	DCX89UH	Verapamil	DD2 (Cell Line: DD2)	[2]
JTC-801 + Thiolactomycin	DCRAHAH	Thiolactomycin	DD2 (Cell Line: DD2)	[2]
JTC-801 + Doxepin	DCWT268	Doxepin	DD2 (Cell Line: DD2)	[2]
JTC-801 + Miconazole	DCMF7R4	Miconazole	DD2 (Cell Line: DD2)	[2]
JTC-801 + MK-4815	DCK88JC	MK-4815	DD2 (Cell Line: DD2)	[2]
JTC-801 + Atovaquone	DCWZFHQ	Atovaquone	DD2 (Cell Line: DD2)	[2]
JTC-801 + Atovaquone	DCXE30Q	Atovaquone	Hepatoblastoma (Cell Line: HB3)	[2]
Mefloquine + JTC-801	DC44JIW	Mefloquine	Hepatoblastoma (Cell Line: HB3)	[2]
MK-4815 + JTC-801	DCY5HH8	MK-4815	DD2 (Cell Line: DD2)	[2]
MK-4815 + JTC-801	DCHXCZK	MK-4815	Hepatoblastoma (Cell Line: HB3)	[3]
Vorinostat + JTC-801	DCSREJ2	Vorinostat	Hepatoblastoma (Cell Line: HB3)	[2]
------------------------------------------------------------------------------------


⏷ Show the Full List of 16 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1692).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.