Details of the Drug Combinations

General Information of This Drug (ID: DMVRIC2)

• Drug Name: Zileuton (DMVRIC2)
• Synonyms: Leutrol; Zileutonum; Ziluton; Zyflo; Abbott brand of zileuton; Zyflo CR; Zyflo Filmtab; A 64077; Abbot 64077; Abbott 64077; A-64077; ABBOTT-64077; ABT-077; CTI-02; ZYFLO (TN); ZYFLO, Zileuton; Zileutonum [INN-Latin]; Zyflo (TN); Zileuton (USP/INN); Zileuton [USAN:INN:BAN]; N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea; N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea; (+-)-1-(1-Benzo(b)thien-2-ylethyl)-1-hydroxyurea; (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea; (+/-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea; 1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea; 1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea

Indication

Allergic asthma; ICD 11: CA23.0; Status: Approved [1]; Asthma; ICD 11: CA23; Status: Approved [2]; Intrinsic asthma; ICD 11: N.A.; Status: Approved [1]

• Therapeutic Class: Antiinflammatory Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

73 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acitretin + Zileuton	DCK8IVU	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Aprepitant + Zileuton	DCOKQ3F	Aprepitant	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Arfolitixorin + Zileuton	DC42SA1	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Artemisinin + Zileuton	DCK04E4	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Auranofin + Zileuton	DC8WXO6	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BIO-300 + Zileuton	DCBH2J9	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bortezomib + Zileuton	DCPPJG4	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Zileuton	DC4PT6G	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chlorzoxazone + Zileuton	DC3KN5E	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Zileuton	DCKMI5B	Citalopram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cytarabine + Zileuton	DCQBJ1C	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Zileuton	DCE3MPC	Dihydroergotamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diphenidol + Zileuton	DCWXESK	Diphenidol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Docetaxel + Zileuton	DC2ERZQ	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Doxorubicin + Zileuton	DCSDV48	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Emetine + Zileuton	DCFSQPW	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Endoxifen + Zileuton	DCMOBRR	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Epinephrine + Zileuton	DCILDXH	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fomepizole + Zileuton	DCBWD9C	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
GINKGOLIDE A + Zileuton	DCM5347	GINKGOLIDE A	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ginsenoside Rb1 + Zileuton	DCF2P6H	Ginsenoside Rb1	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Idarubicin + Zileuton	DCQ5AU8	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
IT-141 + Zileuton	DCC6FEH	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Zileuton	DCHL0WN	Lacosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lumefantrine + Zileuton	DCRBN1A	Lumefantrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maprotiline + Zileuton	DC3PHE0	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Moricizine + Zileuton	DCAIUMG	Moricizine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mycophenolic acid + Zileuton	DCZ6EYT	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Novobiocin + Zileuton	DCZBX68	Novobiocin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Zileuton	DCT6EX8	Olanzapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pentamidine + Zileuton	DCPHI5R	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Zileuton	DCTJ42L	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PHA-739358 + Zileuton	DC0UJFJ	PHA-739358	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Picoplatin + Zileuton	DCFJKXP	Picoplatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pizotyline + Zileuton	DCVASWS	Pizotyline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PMID28460551-Compound-2 + Zileuton	DCR36AC	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pramipexole + Zileuton	DCQX7LA	Pramipexole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Silver sulfadiazine + Zileuton	DCTNCP4	Silver sulfadiazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Terameprocol + Zileuton	DCULT0V	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Zileuton	DCEAA08	Theophylline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tiagabine + Zileuton	DCYV1DU	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trimethobenzamide + Zileuton	DC3L0TG	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ursodeoxycholic acid + Zileuton	DC3COQ4	Ursodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Zileuton	DC0LCYC	Valproic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Vorinostat + Zileuton	DCEH6YX	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
WAY-100635 + Zileuton	DC2WMB0	WAY-100635	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Bepridil	DCDPLWY	Bepridil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Gefitinib	DCU2GK3	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Dantrolene	DCMT52L	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Everolimus	DCOF7DC	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Tranexamic acid	DC2T6X7	Tranexamic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Isosorbide dinitrate	DCD3WX3	Isosorbide dinitrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Efavirenz	DCQ749A	Efavirenz	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Methoxsalen	DCDP39F	Methoxsalen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Clopidogrel	DCYJGS4	Clopidogrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Sulfapyridine	DCTVTWM	Sulfapyridine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Ibutilide	DC0R4MJ	Ibutilide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Diazoxide	DCFPV9V	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Idarubicin	DC393GT	Idarubicin	Glioblastoma? (Cell Line: T98G)	[3]
Zileuton + BRL-15572	DC953Z7	BRL-15572	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Probenecid	DCI7LTA	Probenecid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Darunavir	DCEVAXO	Darunavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Maprotiline	DCD22AN	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Oxyphenbutazone	DCB3Z78	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Leflunomide	DCWIQE9	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Acarbose	DCYDH0X	Acarbose	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Brincidofovir	DCTG8LJ	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Maraviroc	DCRE4XO	Maraviroc	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Mefloquine	DCUN3GM	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Fosfomycin	DC3D80F	Fosfomycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + PMID28870136-Compound-43	DCBKXUX	PMID28870136-Compound-43	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Cerivastatin	DCRW63U	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Raltegravir	DCXBBV7	Raltegravir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]

2 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Celecoxib + Zileuton	DC73PHH	Celecoxib	Tobacco Use Disorder	[4]
Aspirin + Zileuton	DCNCS1P	Aspirin	Tobacco Use Disorder	[5]

References

• [1] Zileuton FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5297).
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] ClinicalTrials.gov (NCT01021215) Zileuton With or Without Celecoxib As Chemopreventive Agents in Smokers
• [5] ClinicalTrials.gov (NCT02348203) Aspirin and Zileuton and Biomarker Expression in Nasal Tissue of Current Smokers