Details of the Drug Combinations

General Information of This Drug (ID: DMWVCF3)

• Drug Name: Fusidic Acid (DMWVCF3)
• Synonyms: FUCIDIN; Fucidate; Fucithalmic; Fusidate; Fusidine; Ramycin; Diethanolamine fusidate; Fucidate Sodium; Fucidic acid; Fucidin acid; Fuci (TN); Fucibet (TN); Fucicort (TN); Fucidin (TN); Fucidin Cream 2%; Fucidine (TN); Fucithalmic (TN); Fucizon (TN); Fudic (TN); Fusiderm (TN); Fusidin (TN); SQ 16,603; Fusidic acid (USAN/INN); C.A.S. 62,602; (2Z)-2-[(17Z)-16beta-acetoxy-3alpha,11alpha-dihydroxy-4alpha,8alpha,10,14beta-tetramethyl-5alpha,9beta,13alpha-gonan-17-ylidene]-6-methylhept-5-enoic acid; (2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid; (2Z)-2-[(3alpha,4alpha,5alpha,8alpha,9beta,11alpha,13alpha,14beta,16beta,17Z)-16-(acetyloxy)-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methylhept-5-enoic acid; 16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic acid; 3.alpha.,11.alpha.,16.beta.-Trihydroxy-29-nor-8.alpha.,9.beta.,13.alpha.,14.beta.-dammara-17(20),24-dien-21-oic acid 16-acetate

Indication

Acne vulgaris; ICD 11: ED80; Status: Approved [1]; Actinomycosis; ICD 11: N.A.; Status: Approved [2]; Acute gonococcal cervicitis; ICD 11: N.A.; Status: Approved [3]; Acute gonococcal epididymo-orchitis; ICD 11: N.A.; Status: Approved [3]; Anthrax; ICD 11: 1B97; Status: Approved [4]; Bacteremia; ICD 11: 1A73; Status: Approved [5]; Bacterial infection; ICD 11: 1A00-1C4Z; Status: Approved [6]; Bartonellosis; ICD 11: N.A.; Status: Approved [3]; Blepharoconjunctivitis; ICD 11: N.A.; Status: Approved [7]; Boutonneuse fever; ICD 11: N.A.; Status: Approved [3]; Brill-Zinsser disease; ICD 11: N.A.; Status: Approved [3]; Bronchitis; ICD 11: CA20; Status: Approved [8]; Brucellosis; ICD 11: N.A.; Status: Approved [3]; Chancroid; ICD 11: N.A.; Status: Approved [3]; Chlamydiaceae infections; ICD 11: N.A.; Status: Approved [9]; Cholangitis; ICD 11: N.A.; Status: Approved [3]; Corneal abrasion; ICD 11: NA06.4; Status: Approved [10]; Cutaneous anthrax; ICD 11: N.A.; Status: Approved [3]; Dacryocystitis; ICD 11: N.A.; Status: Approved [11]; Demodex blepharitis; ICD 11: 1G07; Status: Approved [3]; Endemic typhus; ICD 11: N.A.; Status: Approved [3]; Epidemic louse-borne typhus; ICD 11: N.A.; Status: Approved [3]; Folliculitis; ICD 11: N.A.; Status: Approved [12]; Gastrointestinal anthrax; ICD 11: N.A.; Status: Approved [3]; Inhalational anthrax; ICD 11: N.A.; Status: Approved [3]; Listeriosis; ICD 11: N.A.; Status: Approved [13]; Lymphogranuloma venereum; ICD 11: N.A.; Status: Approved [3]; Mycoplasma pneumoniae pneumonia; ICD 11: N.A.; Status: Approved [3]; Neonatal sepsis; ICD 11: N.A.; Status: Approved [14]; Ornithosis; ICD 11: N.A.; Status: Approved [3]; Paronychia; ICD 11: 1F23.13; Status: Approved [15]; Peritonitis; ICD 11: N.A.; Status: Approved [16]; Pneumococcal infection; ICD 11: CA00-CA40; Status: Approved [17]; Pneumonia; ICD 11: CA40; Status: Approved [18]; Pseudomonas aeruginosa infectious disease; ICD 11: N.A.; Status: Approved [19]; Q fever; ICD 11: N.A.; Status: Approved [3]; Relapsing fever; ICD 11: N.A.; Status: Approved [3]; Rickettsialpox; ICD 11: N.A.; Status: Approved [3]; Rickettsiosis; ICD 11: N.A.; Status: Approved [3]; Rocky mountain spotted fever; ICD 11: N.A.; Status: Approved [3]; Rosacea; ICD 11: ED90.0; Status: Approved [20]; Staphylococcal pneumonia; ICD 11: N.A.; Status: Approved [21]; Staphylococcus aureus infection; ICD 11: N.A.; Status: Approved [22]; Streptococcus infection; ICD 11: 1B53; Status: Approved [23]; Syphilis; ICD 11: N.A.; Status: Approved [24]; Trachoma; ICD 11: N.A.; Status: Approved [3]; Tularemia; ICD 11: 1B94; Status: Approved [3]; Typhus; ICD 11: N.A.; Status: Approved [3]; Urinary tract infection; ICD 11: GC08; Status: Approved [25]; Yaws; ICD 11: N.A.; Status: Approved [3]; MRSA infection; ICD 11: 1D01.0Y; Status: Phase 3 [26]; Sinusitis; ICD 11: CA0A.Z; Status: Investigative [27]; Vibrio cholerae infection; ICD 11: 1A00; Status: Investigative [3]

• Therapeutic Class: Antibiotics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

2 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Erlotinib + Fusidic acid	DCIHJX7	Erlotinib	Non-Small Cell Lung Cancer	[28]
Rifampicin + Fusidic acid	DCQY3NA	Rifampicin	Prosthetic Joint Infections of Hip	[29]

References

• [1] Curcumin/Fusidic Acid Bitherapy Loaded Mixed Micellar Nanogel for Acne Vulgaris Treatment: In Vitro and In Vivo Studies. AAPS PharmSciTech. 2023 Sep 11;24(7):182.
• [2] [In vitro sensitivity of Actinomyces israelii, Actinobacillus actinomycetem-comitans and Bacteroides melaninogenicus to cephalothin, cephaloridine, gentamicin, fusidic acid and lincomycin]. Int Z Klin Pharmakol Ther Toxikol. 1970 Oct;3(4):318-20.
• [3] A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
• [4] Cationic quaternized aminocalix[4]arenes: cytotoxicity, haemolytic and antibacterial activities. Int J Pharm. 2013 Dec 15;458(1):25-30.
• [5] Genetic determinants of resistance to fusidic acid among clinical bacteremia isolates of Staphylococcus aureus. Antimicrob Agents Chemother. 2009 May;53(5):2059-65.
• [6] Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92.
• [7] Fusidic acid viscous eyedrops--an evaluation of pharmacodynamics, pharmacokinetics and clinical use for UK optometrists. Ophthalmic Physiol Opt. 2006 Jul;26(4):343-61.
• [8] [Interferon-gamma receptor 1 deficiency in a 19-month-old child: case report and literature review]. Zhonghua Er Ke Za Zhi. 2014 May;52(5):387-91.
• [9] The in vitro effects of proxymetacaine, fluorescein, and fusidic acid on real-time PCR assays used for the diagnosis of Feline herpesvirus 1 and Chlamydophila felis infections. Vet Ophthalmol. 2011 Sep;14 Suppl 1:5-8.
• [10] Antibiotic prophylaxis for corneal abrasion. Cochrane Database Syst Rev. 2022 May 27;5(5):CD014617.
• [11] [Susceptibility of drug-resistant staphylococci isolated from different parts of the ocular anterior segment to common ophthalmic antibiotics]. Zhonghua Yan Ke Za Zhi. 2022 Aug 11;58(8):598-605.
• [12] Fusidic acid betamethasone lipid cream. Int J Clin Pract. 2016 May;70 Suppl 184:4-13.
• [13] Antimicrobial Resistance of Listeria monocytogenes from Animal Foods to First- and Second-Line Drugs in the Treatment of Listeriosis from 2008 to 2021: A Systematic Review and Meta-Analysis. Can J Infect Dis Med Microbiol. 2022 Oct 7;2022:1351983.
• [14] Microbiological Characteristics and Resistance Patterns in a Neonatal Intensive Care Unit: A Retrospective Surveillance Study. Cureus. 2024 Mar 12;16(3):e56027.
• [15] Extensive pyomyositis secondary to paronychia-related MRSA infection: A case report. Medicine (Baltimore). 2022 Jan 14;101(2):e28431.
• [16] An experimental evaluation of the pharmacokinetics of fusidic acid in peritoneal dialysis. J Med Microbiol. 1992 Feb;36(2):71-7.
• [17] Epidemiology of penicillin resistant pneumococci in Iceland. Microb Drug Resist. 1995 Summer;1(2):121-5.
• [18] Mycoplasma pneumoniae-associated mucositis. BMJ Case Rep. 2021 Apr 15;14(4):e239086.
• [19] Bacterial profile of diabetic foot infections and antibiotic susceptibility in a specialized diabetes centre in Cameroon. Pan Afr Med J. 2022 May 18;42:52.
• [20] Placebo controlled trial of fusidic acid gel and oxytetracycline for recurrent blepharitis and rosacea. Br J Ophthalmol. 1995 Jan;79(1):42-5.
• [21] Fusidic acid in other infections. Int J Antimicrob Agents. 1999 Aug;12 Suppl 2:S11-5.
• [22] Registered and investigational drugs for the treatment of methicillin-resistant Staphylococcus aureus infection. Recent Pat Antiinfect Drug Discov. 2008 Jan;3(1):10-33.
• [23] Impetigo: diagnosis and treatment. Am Fam Physician. 2014 Aug 15;90(4):229-35.
• [24] Balanoposthitis and Penile Edema: Atypical Manifestations of Primary Syphilis. Sex Transm Dis. 2015 Sep;42(9):524-5.
• [25] Isolation of Staphylococcus aureus Urinary Tract Infections at a Community-Based Healthcare Center in Riyadh. Cureus. 2023 Feb 18;15(2):e35140.
• [26] Application of pharmacokinetic-pharmacodynamic modeling and the justification of a novel fusidic acid dosing regimen: raising Lazarus from the dead. Clin Infect Dis. 2011 Jun;52 Suppl 7:S513-9.
• [27] Facial cellulitis associated with Pseudomonas aeruginosa complicating ophthalmic herpes zoster. Dermatol Online J. 2004 Oct 15;10(2):20.
• [28] ClinicalTrials.gov (NCT00718315) A Study of Verutex (Fusidic Acid), Eritex (Erythromycin) and Fisiogel in the Management of Tarceva-Associated Rash.
• [29] ClinicalTrials.gov (NCT01756924) Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection