Details of the Drug Combinations

General Information of This Drug (ID: DMXKJ6C)

• Drug Name: Torasemide (DMXKJ6C)
• Synonyms: Demadex; Dilutol; Luprac; Presoril; Sutril; TORSEMIDE; Toradiur; Torasemida; Torasemidum; Torem; Torocard; Torrem; Unat; Torasemide N; Torsemide [USAN]; AC 4464; BM 02015; JDL 464; BM-02015; Demadex (TN); Demadex, Torsemide; GJ-1090; JDL-464; KS-1123; Luprac (TN); PW-2132; Torasemida [INN-Spanish]; Torasemidum [INN-Latin]; Torsemide (USP); Torasemide (JAN/INN); N-(Isopropylcarbamoyl)-4-(m-tolylamino)pyridine-3-sulfonamide; N-{[(1-methylethyl)amino]carbonyl}-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide; N-(((1-Methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-3-pyridinesulfonamide; 1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea; 1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea; 1-isopropyl-3-((4-(3-methylphenylamino)pyridine)-3-sulfonyl)urea; 1-isopropyl-3-[(4-m-toluidino-3-pyridyl) sulfonyl]urea

Indication

Congestive heart failure; ICD 11: BD10; Status: Approved [1]; Edema; ICD 11: MG29; Status: Approved [2]; Renal hypoplasia; ICD 11: N.A.; Status: Approved [3]

• Therapeutic Class: Diuretics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Furosemide + Torasemide	DCFPPXI	Furosemide	Renal Impairment	[4]
Potassium Citrate + Torasemide	DCCCS4I	Potassium Citrate	Congenital Mitral Insufficiency	[5]
Potassium Citrate + Torasemide	DCEC9GY	Potassium Citrate	Heart Failure Congenital	[6]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7312).
• [2] Comparative effects of furosemide and other diuretics in the treatment of heart failure: a systematic review and combined meta-analysis of randomized controlled trials. Heart Fail Rev. 2021 Jan;26(1):127-136.
• [3] Torsemide. 2023 Jul 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 JanC.
• [4] ClinicalTrials.gov (NCT01558674) A Study of MK-7145 in Participants With Renal Insufficiency (Part I) and Heart Failure With Renal Insufficiency (Part II) (MK-7145-011)
• [5] ClinicalTrials.gov (NCT06037434) Study of Innovative Drug Treatment Therapy for Pediatric Mitral Regurgitation
• [6] ClinicalTrials.gov (NCT06039540) Study of Drug Therapy for Pediatric Heart Failure