Details of the Drug Combinations

General Information of This Drug (ID: DMXY30O)

• Drug Name: Dipyridamole (DMXY30O)
• Synonyms: Agilease; Anginal; Antistenocardin; Apricor; Cardioflux; Cardoxil; Cardoxin; Cerebrovase; Chilcolan; Cleridium; Coribon; Coridil; Coronarine; Corosan; Coroxin; Curantil; Curantyl; Dipiridamol; Dipyramidole; Dipyridamine; Dipyridamol; Dipyridamolum; Dipyridan; Dipyudamine; Dypyridamol; Gulliostin; Justpertin; Kurantil; Miosen; Natyl; Peridamol; Permiltin; Persantin; Persantine; Piroan; Prandiol; Protangix; Stenocardil; Stenocardiol; Stimolcardio; Apotex Brand of Dipyridamole; Ashbourne Brand of Dipyridamole; Belmac Brand of Dipyridamole; Berlin Chemie Brand of Dipyridamole; Boehringer Ingelheim Brand of Dipyridamole; IPRAD Brand of Dipyridamole; Iv Persantine; Novopharm Brand of Dipyridamole; Cleridium 150; D 9766; Prandiol 75; Apo-Dipyridamole; Apo-Dipyridamole Fc; Apo-Dipyridamole Sc; Berlin-Chemie Brand of Dipyridamole; Dipiridamol [INN-Spanish]; Dipyridamolum [INN-Latin]; Novo-Dipiradol; Persantine (TN); RA-8; Usaf Ge-12; Dipyridamole (JP15/USP/INN); Dipyridamole [USAN:INN:BAN:JAN]; Permole, Persantine, Dipyridan, Dipyridamole; 2,6-Bis(diethanolamine)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine; 2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido(5,4-d)pyrimidine; 2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine

Indication

Atrial fibrillation; ICD 11: BC81.3; Status: Approved [1]; Chronic heart failure; ICD 11: BD1Z; Status: Approved [1]; Hypertension; ICD 11: BA00-BA04; Status: Approved [2]; Malignant essential hypertension; ICD 11: BA00; Status: Approved [1]

• Therapeutic Class: Vasodilator Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Dipyridamole + Ruxolitinib	DC5L20R	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Caffeine + Dipyridamole	DCDONMW	Caffeine	Cardiovascular Disease	[4]
Prednisone + Dipyridamole	DCLZX45	Prednisone	Rheumatoid arthritis	[5]
BREQUINAR + Dipyridamole	DCZXJZQ	BREQUINAR	COVID-19	[6]
Adenosine + Dipyridamole	DCCMTEM	Adenosine	Takotsubo Syndrome	[7]

References

• [1] Dipyridamole FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4807).
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] ClinicalTrials.gov (NCT00430170) Does Caffeine Reduce Dipyridamole-Induced Protection Against Ischemia-Reperfusion Injury?
• [5] ClinicalTrials.gov (NCT01612377) Long Term Safety Trial of z102 and Prednisone in Patients With Moderate to Severe Rheumatoid Arthritis. U.S. National Institutes of Health.
• [6] ClinicalTrials.gov (NCT05166876) Brequinar Combined With Dipyridamole in Patients With Mild to Moderate COVID-19
• [7] ClinicalTrials.gov (NCT04666454) BROKEN-SWEDEHEART- Optimized Pharmacological Treatment for Broken Heart (Takotsubo) Syndrome.