Details of the Drug Combinations

General Information of This Drug (ID: DMZIM37)

Drug Name

CP-868596 DMZIM37

Synonyms

Crenolanib; 670220-88-9; Crenolanib (CP-868596); ARO-002; UNII-LQF7I567TQ; LQF7I567TQ; CP-868596 (Crenolanib); CP-868,596; [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine; 1-(2-(5-((3-Methyloxetan-3-yl)methoxy)-1H-benzo-[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine; CP868569; 1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1-benzimidazolyl]-8-quinolyl]-4-piperidinamine; J-502712; 1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine

Indication

Disease Entry	ICD 11	Status	REF
Gastrointestinal cancer	2C11	Phase 3	[1]
Gastrointestinal stromal tumour	2B5B	Phase 3	[2]
Acute myelogenous leukaemia	2A41	Phase 2	[3]
Acute myeloid leukaemia	2A60	Phase 2	[2]
Malignant glioma	2A00.0	Phase 1	[3]
------------------------------------------------------------------------------------

Therapeutic Class

Anticancer Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
CP-868596 + Formononetin	DCJCNNN	Formononetin	Ewing sarcoma (Cell Line: TC-71)	[4]
CP-868596 + Idarubicin	DC0PQFL	Idarubicin	Glioblastoma? (Cell Line: T98G)	[4]
CP-868596 + LY3023414	DC578PJ	LY3023414	Hodgkin lymphoma (Cell Line: L-1236)	[5]
Exherin + CP-868596	DC3NBGU	Exherin	Ewing sarcoma (Cell Line: TC-71)	[4]
GDC-0084 + CP-868596	DCX00PF	GDC-0084	Ewing sarcoma (Cell Line: TC-71)	[4]
Nintedanib + CP-868596	DCHOZO2	Nintedanib	Ewing sarcoma (Cell Line: TC-71)	[4]
------------------------------------------------------------------------------------


⏷ Show the Full List of 6 DrugCom(s)

1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Azacitidine + CP-868596	DCSEWL4	Azacitidine	Acute Myeloid Leukemia	[6]
------------------------------------------------------------------------------------

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7882).
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
6	ClinicalTrials.gov (NCT02400281) Study of Crenolanib Combined With Chemotherapy in FLT3-mutated Acute Myeloid Leukemia Patients