Details of the Drug Formulations

General Information of Drug (ID: DM1WXA6)

• Drug Name: Lofexidine Drug Info
• Synonyms: Britlofex; Lofexidina; Lofexidinum; Britlofex (TN); Lofexidina [INN-Spanish]; Lofexidine (INN); Lofexidine [INN:BAN]; Lofexidinum [INN-Latin]; 1H-Imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-(9CI); 2-(1-(2,6-Dichlorophenoxy)ethyl)-4,5-dihydro-1H-imidazole; 2-(a-(2,6-dichlorophenoxy)ethyl)2-imidazoline; 2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline; 2-(alpha-(2,6-dichlorophenoxy)ethyl) delta-2-imidazoline; 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole; 2-{1-[(2,6-dichlorophenyl)oxy]ethyl}-4,5-dihydro-1H-imidazole

Indication

Disease Entry	ICD 11	Status	REF
Heroin and opiate withdrawal	6C43	Approved	[1]
Opioid dependence	6C43.2Z	Approved	[2]

• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 30668
  ChEBI ID: CHEBI:51368
  CAS Number: 31036-80-3
  TTD ID: D0K0MW
  INTEDE ID: DR0967
  ACDINA ID: D01217

Full List of Drug Formulations Containing This Drug

Lofexidine 0.18 mg tablet

Company	Formulation ID	FDA Description
Uswm	F23214	Lactose; Citric Acid; Povidone; Microcrystalline Cellulose; Calcium Stearate; Sodium Lauryl Sulphate; Indigo Carmine; Sunset Yellow

References

• [1] A Phase 3 placebo-controlled, double-blind, multi-site trial of the alpha-2-adrenergic agonist, lofexidine, for opioid withdrawal. Drug Alcohol Depend. 2008 Sep 1;97(1-2):158-68.
• [2] 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.