Details of the Drug Formulations

General Information of Drug (ID: DMBS370)

Drug Name
Tofacitinib Drug Info
Synonyms
Tasocitinib; 477600-75-2; 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; CP-690550; CP 690550; racemic-tofacitinib; 1259404-17-5; tofacitinibum; CP-690,550; UNII-87LA6FU830; 3-((3R,4R)-rel-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile; Tofacitinib (CP-690550,Tasocitinib); CHEMBL221959; CHEBI:71200; Xeljanz (TN)
Indication
Disease Entry ICD 11 Status REF
Rheumatoid arthritis FA20 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [2]
Cross-matching ID
PubChem CID
9926791
ChEBI ID
CHEBI:71200
CAS Number
477600-75-2
TTD ID
D0EG1I
INTEDE ID
DR1610
ACDINA ID
D00683

Full List of Drug Formulations Containing This Drug

Tofacitinib Citrate eq 10mg base tablet
Company Formulation ID FDA Description
Pf Prism Cv F23572 Croscarmellose Sodium; Fd&C Blue 1/Brilliant Blue Fcf Aluminum Lake; Fd&C Blue 2/Indigo Carmine Aluminum Lake; Hpmc 2910/Hypromellose 6Cp; Lactose Monohydrate; Macrogol/Peg3350; Magnesium Stearate; Microcrystalline Cellulose; Titanium Dioxide; Triacetin
------------------------------------------------------------------------------------
Tofacitinib Citrate eq 22mg base extended release tablet
Company Formulation ID FDA Description
Pfizer F23570 Cellulose Acetate; Copovidone; Fd&C Blue 2 Aluminum Lake; Hydroxyethyl Cellulose; Hydroxypropyl Cellulose; Hpmc 2910/Hypromellose; Magnesium Stearate; Red Iron Oxide; Sorbitol; Titanium Dioxide; Triacetin; Yellow Iron Oxide; Printing Ink Contains Ammonium Hydroxide; Ferrosoferric Oxide/Black Iron Oxide; Propylene Glycol; Shellac Glaze
------------------------------------------------------------------------------------
Tofacitinib Citrate eq 11mg base extended release tablet
Company Formulation ID FDA Description
Pfizer F23571 Cellulose Acetate; Copovidone; Hydroxyethyl Cellulose; Hydroxypropyl Cellulose; Hpmc 2910/Hypromellose; Magnesium Stearate; Red Iron Oxide; Sorbitol; Titanium Dioxide; Triacetin; Printing Ink Contains Ammonium Hydroxide; Ferrosoferric Oxide/Black Iron; Propylene Glycol; Shellac Glaze
------------------------------------------------------------------------------------
Tofacitinib Citrate eq 5mg base tablet
Company Formulation ID FDA Description
Pf Prism Cv F23573 Croscarmellose Sodium; Hpmc 2910/Hypromellose 6Cp; Lactose Monohydrate; Macrogol/Peg3350; Magnesium Stearate; Microcrystalline Cellulose; Titanium Dioxide; Triacetin
------------------------------------------------------------------------------------
Tofacitinib Citrate eq 1mg base/ml solution
Company Formulation ID FDA Description
Pfizer F23574 Grape Flavor (Natural); Hydrochloric Acid; Lactic Acid; Purified Water; Sodium Benzoate; Sucralose; Xylitol
------------------------------------------------------------------------------------
Tofacitinib 5 mg tablet
Company Formulation ID FDA Description
Pfizer Laboratories; U.S. Pharmaceuticals F21190 Lactose monohydrate; Magnesium stearate; Titanium dioxide; Triacetin; Croscarmellose sodium; Polyethylene glycol 3350; Hypromellose 2910 (6 mpa.s); Microcrystalline cellulose
------------------------------------------------------------------------------------
Tofacitinib 11 mg tablet
Company Formulation ID FDA Description
U.S. Pharmaceuticals F21188 Magnesium stearate; Sorbitol; Ammonia; Ferric oxide red; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Triacetin; Cellulose acetate; Copovidone; Hydroxyethyl cellulose (140 mpa.s at 5%); Hydroxypropyl cellulose (1200000 mw); Hypromellose 2910 (6 mpa.s); Shellac
Pfizer Laboratories F21189 Magnesium stearate; Sorbitol; Ammonia; Ferric oxide red; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Triacetin; Cellulose acetate; Copovidone k25-31; Hydroxyethyl cellulose (140 mpa.s at 5%); Hydroxypropyl cellulose (1200000 mw); Hypromellose 2910 (6 mpa.s); Shellac
------------------------------------------------------------------------------------

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5677).
2 ClinicalTrials.gov (NCT04332042) TOFAcitinib in SARS-CoV2 Pneumonia. U.S. National Institutes of Health.