Details of the Drug Formulations

General Information of Drug (ID: DMK2GZX)

• Drug Name: Avapritinib Drug Info
• Synonyms: 1703793-34-3; UNII-513P80B4YJ; 513P80B4YJ; (1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine; Avapritinib [INN]; BLU-285 (Avapritinib); SCHEMBL16652297; EX-A1366; BCP20175; CS-7577; ACN-051245; HY-101561; (S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethanamine

Indication

Disease Entry	ICD 11	Status	REF
Gastrointestinal stromal tumour	2B5B	Approved	[1]
Mast cell leukaemia	2A21.00	Phase 1	[2]
Systemic mastocytosis	2A21.0	Phase 1	[3]

• Cross-matching ID:
  PubChem CID: 118023034
  CAS Number: 1703793-34-3
  TTD ID: D0UO2P
  ACDINA ID: D01518

Full List of Drug Formulations Containing This Drug

Vapritinib 200mg tablet

Company	Formulation ID	FDA Description
Blueprint Medicines	F24158	Copovidone; Croscarmellose Sodium; Magnesium Stearate; Microcrystalline Cellulose; Polyethylene Glycol; Polyvinyl Alcohol; Talc; Titanium Dioxide

Vapritinib 300mg tablet

Company	Formulation ID	FDA Description
Blueprint Medicines	F24159	Copovidone; Croscarmellose Sodium; Magnesium Stearate; Microcrystalline Cellulose; Polyethylene Glycol; Polyvinyl Alcohol; Talc; Titanium Dioxide

Vapritinib 100mg tablet

Company	Formulation ID	FDA Description
Blueprint Medicines	F24160	Copovidone; Croscarmellose Sodium; Magnesium Stearate; Microcrystalline Cellulose; Polyethylene Glycol; Polyvinyl Alcohol; Talc; Titanium Dioxide

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)