Details of the Drug Formulations

General Information of Drug (ID: DMOLNHF)

Drug Name
Melphalan Drug Info
Synonyms
Alkeran; Levofalan; Levofolan; Levopholan; Melfalan; Melfalano; Melphalanum; Alanine Nitrogen Mustard; Phenylalanine mustard; Phenylalanine nitrogen mu stard; Phenylalanine nitrogen mustard; AY3360000; CB 3025; ALKERAN (TN); Alkeran (TN); At-290; CB-3025; L-PAM; L-Phenylalanine mustard; L-Sarcolysin; L-Sarcolysine; L-Sarkolysin; Melfalano [INN-Spanish]; Melphalanum [INN-Latin]; SK-15673; TRANSGENIC MODEL EVALUATION (MELPHALAN); MELPHALAN (SEE ALSO TRANSGENIC MODEL EVALUATION (MELPHALAN)); P-L-Sarcolysin; P-L-sarcolysine; TRANSGENIC LEP (MELPHALAN) (SEE ALSO MELPHALAN); Melphalan (JP15/USP/INN); Melphalan [USAN:INN:BAN:JAN]; P-Bis(beta-chloroethyl)aminophenylalanine; P-N-Di(chloroethyl)aminophenylalanine; P-N-di(chloroethyl)aminophenylala nine; P-Di-(2-chloroethyl)amino-L-phenylalanine; P-N-Bis(2-chloroethyl)amino-L-phenylalanine; L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine; L-3-(para-(Bis(2-chloroethyl)amino)phenyl)alanine; P-N,N-bis(2-chloroethyl)amino-L-phenylalanine; (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid; (2s)-2-amino-3-(4-[bis(2-chloroethyl)amino]phenyl)propanoic acid; 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine; 3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine; 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine; 4-(Bis(2-chloroethyl)amino)-L-phenylalanine; 4-[Bis(2-chloroethyl)amino]-L-phenylalanine; 4-[Bis-(2-chloroethyl)amino]-L-phenylalanine
Indication
Disease Entry ICD 11 Status REF
Hematologic disease 3C0Z Approved [1]
Leukemia Approved [1]
Multiple myeloma 2A83 Approved [2]
Myeloproliferative neoplasm 2A20 Approved [1]
Ovarian cancer 2C73 Approved [3]
Plasma cell myeloma 2A83.1 Approved [1]
Refractory plasma cell neoplasm Approved [1]
Intrahepatic cholangiocarcinoma 2C12.10 Phase 3 [4]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [5]
Classic Hodgkin lymphoma Investigative [1]
Neuroblastoma 2D11.2 Investigative [1]
Retinoblastoma 2D02.2 Investigative [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
460612
ChEBI ID
CHEBI:28876
CAS Number
148-82-3
TTD ID
D00FGO
VARIDT ID
DR00379
INTEDE ID
DR1021
ACDINA ID
D00394

Full List of Drug Formulations Containing This Drug

Melphalan 2 mg tablet
Company Formulation ID FDA Description
ApoPharma USA F12943 Magnesium stearate; Titanium dioxide; Crospovidone; Polyethylene glycol 400; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
Alvogen F12942 Magnesium stearate; Titanium dioxide; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Hypromellose, unspecified; Microcrystalline cellulose; Polyethylene glycol, unspecified
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References

1 Melphalan FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7620).
3 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 201379.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 ClinicalTrials.gov (NCT04380376) Low-doses Melphalan Inhalation in Patients With COVID-19 (CoronavIrus Disease 2019) Pneumonia. U.S. National Institutes of Health.