Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM0C5O3)

Drug Name

2-(Biphenyl-2-yloxy)-N,N-dimethylethanamine Drug Info

Synonyms

CHEMBL20666; N,N-dimethyl-2-(2-phenylphenoxy)ethanamine; 2-(Biphenyl-2-yloxy)-N,N-dimethylethanamine; AC1LHJ83; ZINC4913607; BDBM50307494; MCULE-6428005896

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 888197
TTD Drug ID: DM0C5O3

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 7 receptor (HTR7)	TTO9X1H	5HT7R_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 7 receptor (HTR7)	DTT	HTR7	1.561	1.233	0.848	1.485

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 7 receptor (HTR7)	DTT	HTR7	9.79E-01	-0.08	-0.32

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling. Bioorg Med Chem. 2010 Mar 1;18(5):1958-67.