Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM0I6UT)

Drug Name

3,4-Dihydro-1H-quinolin-(2E)-ylideneamine Drug Info

Synonyms

CHEMBL6656; 2-amino-3,4-dihydroquinoline; 1,2,3,4-tetrahydroquinolin-2-imine; AC1N2ULT; 3,4-Dihydro-1H-quinolin-(2E)-ylideneamine; 3,4-dihydroquinolin-2-amine; SCHEMBL2075410; RREBANHDFAXBEZ-UHFFFAOYSA-N; MolPort-005-905-447; HMS1726J17; 3,4-Dihydroquinolin-2(1H)-imine; ZINC13014981; BDBM50062129; AKOS006221851; AKOS008024789; MCULE-1322063466; 3,4-Dihydro-1H-quinolin-(2Z)-ylideneamine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 4102304
TTD Drug ID: DM0I6UT

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nitric-oxide synthase brain (NOS1)	TTZUFI5	NOS1_HUMAN	Inhibitor	[1]
Nitric-oxide synthase inducible (NOS2)	TTF10I9	NOS2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	6.085	5.844	5.849	5.806
Nitric-oxide synthase inducible (NOS2)	DTT	NOS2	4.95	5.198	4.573	5.121

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Nitric-oxide synthase inducible (NOS2)	DTT	NOS2	4.24E-02	-0.27	-0.88

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inh... Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001.