Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM0KFW2)

Drug Name

H-Phe-Phe-NH2 Drug Info

Synonyms

CHEMBL108438; 15893-46-6; Phe-phe-amide; Phenylalanylphenylalanylamide; L-Phe-L-phe-amide; H-Phe-Phe-NH2; L-Phenylalanine-L-phenylalanylamide; L-Phe-L-Phe-NH2; AC1L38WX; XXPXQEQOAZMUDD-HOTGVXAUSA-N; L-Phenylalaninamide, L-phenylalanyl-; BDBM50188489; (S)-2-Amino-N-((S)-1-carbamoyl-2-phenyl-ethyl)-3-phenyl-propionamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 85169
CAS Number: CAS 15893-46-6
TTD Drug ID: DM0KFW2

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Substance-P receptor (TACR1)	TTZPO1L	NK1R_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Substance-P receptor (TACR1)	DTT	TACR1	3.597	4.186	4.271	5.113

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Substance-P receptor (TACR1)	DTT	TACR1	7.40E-01	0.02	0.07
Substance-P receptor (TACR1)	DTT	TACR1	8.57E-01	-0.02	-0.18

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9.