Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM0L3GE)

Drug Name
(+/-)-nantenine Drug Info
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
181743
CAS Number
CAS 42971-15-3
TTD Drug ID
DM0L3GE

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 1B receptor (HTR1B) TTK8CXU 5HT1B_HUMAN Inhibitor [1]
5-HT 1D receptor (HTR1D) TT6MSOK 5HT1D_HUMAN Inhibitor [1]
5-HT 2A receptor (HTR2A) TTJQOD7 5HT2A_HUMAN Inhibitor [1]
5-HT 2B receptor (HTR2B) TT0K1SC 5HT2B_HUMAN Inhibitor [1]
5-HT 2C receptor (HTR2C) TTWJBZ5 5HT2C_HUMAN Inhibitor [1]
5-HT 5A receptor (HTR5A) TTRUFDT 5HT5A_HUMAN Inhibitor [1]
5-HT 6 receptor (HTR6) TTJS8PY 5HT6R_HUMAN Inhibitor [1]
5-HT 7 receptor (HTR7) TTO9X1H 5HT7R_HUMAN Inhibitor [1]
Adrenergic receptor alpha-1A (ADRA1A) TTNGILX ADA1A_HUMAN Inhibitor [1]
Adrenergic receptor alpha-1B (ADRA1B) TTBRKXS ADA1B_HUMAN Inhibitor [1]
Adrenergic receptor alpha-1D (ADRA1D) TT34BHT ADA1D_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2A (ADRA2A) TTWG9A4 ADA2A_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2B (ADRA2B) TTWM4TY ADA2B_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2C (ADRA2C) TT2NUT5 ADA2C_HUMAN Inhibitor [1]
Adrenergic receptor beta-1 (ADRB1) TTR6W5O ADRB1_HUMAN Inhibitor [1]
Dopamine D1 receptor (D1R) TTZFYLI DRD1_HUMAN Inhibitor [1]
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Inhibitor [1]
Dopamine D3 receptor (D3R) TT4C8EA DRD3_HUMAN Inhibitor [1]
Dopamine D4 receptor (D4R) TTE0A2F DRD4_HUMAN Inhibitor [1]
Dopamine D5 receptor (D5R) TTS2PH3 DRD5_HUMAN Inhibitor [1]
Histamine H2 receptor (H2R) TTQHJ1K HRH2_HUMAN Inhibitor [1]
Opioid receptor mu (MOP) TTKWM86 OPRM_HUMAN Inhibitor [1]
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Dopamine D1 receptor (D1R) DTT DRD1 5.04 4.626 2.459 1.322
5-HT 2C receptor (HTR2C) DTT HTR2C 4.233 3.329 3.843 3.888
Dopamine D5 receptor (D5R) DTT DRD5 7.097 6.724 6.896 7.369
Histamine H2 receptor (H2R) DTT HRH2 5.087 5.121 4.661 4.609
5-HT 7 receptor (HTR7) DTT HTR7 1.561 1.233 0.848 1.485
Adrenergic receptor alpha-1A (ADRA1A) DTT ADRA1A 3.154 3.853 4.129 2.963
Opioid receptor mu (MOP) DTT OPRM1 4.548 5.062 4.652 4.776
5-HT 1B receptor (HTR1B) DTT HTR1B 5.781 3.121 6.267 4.986
5-HT 6 receptor (HTR6) DTT HTR6 5.594 5.781 5.271 3.963
5-HT 2A receptor (HTR2A) DTT HTR2A 4.84 4.904 4.652 4.129
Dopamine D2 receptor (D2R) DTT DRD2 5.345 5.634 5.789 5.901
Dopamine D4 receptor (D4R) DTT DRD4 2.138 1.766 1.322 1
5-HT 1D receptor (HTR1D) DTT HTR1D 3.307 1.263 2.585 5.833
Dopamine D3 receptor (D3R) DTT DRD3 1.379 2.446 1.233 1.07
Serotonin transporter (SERT) DTT SLC6A4 6.278 5.469 6.075 6.966
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 5.013 2.379 5.594 2.07
5-HT 2B receptor (HTR2B) DTT HTR2B 0.485 3.536 0.379 4.667
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
5-HT 6 receptor (HTR6) DTT HTR6 1.23E-05 -0.12 -0.71
Dopamine D2 receptor (D2R) DTT DRD2 2.50E-02 -0.08 -0.49
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 1.76E-01 -0.06 -0.28
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31.