Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM0P5Z9)

• Drug Name: UCL1972 Drug Info
• Synonyms: CHEMBL289855; UCL-1972; 1-[5-(4-nitrophenoxy)pentyl]pyrrolidine; 1-(5-(4-nitrophenoxy)pentyl)pyrrolidine; SCHEMBL490968; BDBM50089295; 1-[5-(4-Nitro-phenoxy)-pentyl]-pyrrolidine; L019446

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 9925627
  TTD Drug ID: DM0P5Z9

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H3 receptor (H3R)	TT9JNIC	HRH3_HUMAN	Antagonist	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Histamine H3 receptor (H3R)	DTT	HRH3	3.225	3.399	3.17	3.027

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histamine H3 receptor (H3R)	DTT	HRH3	3.62E-02	-0.09	-0.22

References

• [1] The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20.