General Information of Drug (ID: DM0TS21)

Drug Name
N5-(1-iminopent-3-enyl)-L-ornithine Drug Info
Synonyms Propenyl-L-NIO; hDDAH inhibitor, 1c; L-ENIPO; MolPort-009-019-384; JUSNBVJTFYDFKR-SGJFDWMWSA-N; BDBM235686; ZINC100017163; L-N5-(1-Imino-3-pentenyl) ornithine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
91935312
TTD Drug ID
DM0TS21

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Nitric-oxide synthase brain (NOS1) TTZUFI5 NOS1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Nitric-oxide synthase brain (NOS1) DTT NOS1 6.085 5.844 5.849 5.806
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Nitric-oxide synthase brain (NOS1) DTT NOS1 5.20E-01 0.02 0.07
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9.