Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM0W2TA)

Drug Name

HGS-TR2J Drug Info

Synonyms

KMTR2; Trail-R2 human antibody; TRAIL-R2 mAbs, HGS/Kirin; TRAIL-R2 monoclonal antibody (cancer), Human Genome Sciences/Kirin; TRAIL-R2 monoclonal antibody (cancer), Human Genome Sciences/Kyowa Hakko Kirin

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 1	[1]

Cross-matching ID

TTD Drug ID: DM0W2TA

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TRAIL receptor 2 (TRAIL-R2)	TTW20TU	TR10B_HUMAN	Not Available	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
TRAIL receptor 2 (TRAIL-R2)	DTT	TNFRSF10B	5.914	2.963	5.311	3.744

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Solid tumour/cancer

ICD Disease Classification

2A00-2F9Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
TRAIL receptor 2 (TRAIL-R2)	DTT	TNFRSF10B	1.03E-05	1.09	4.71

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021611)
2	Enhancement of Glioma Radiation Therapy and Chemotherapy Response with Targeted Antibody Therapy Against Death Receptor 5. Int J Radiat Oncol Biol Phys. 2008 June 1; 71(2): 507-516.