Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM10A9S)

Drug Name

6-Chloro-N-(2-morpholinoethyl)nicotinamide Drug Info

Synonyms

6-Chloro-N-(2-morpholinoethyl)nicotinamide; CHEMBL596768; 446269-58-5; 6-chloro-N-[2-(morpholin-4-yl)ethyl]pyridine-3-carboxamide; AC1LNWHD; Oprea1_139589; MLS001010907; CTK6H1374; cid_1228702; 6-chloro-N-(2-morpholin-4-ylethyl)pyridine-3-carboxamide; MolPort-000-431-678; HMS2765K07; ZINC19397174; BDBM50307188; AKOS000162940; MCULE-8413919053; SMR000352965; ST50046456; 6-chloro-N-(2-morpholin-4-ylethyl)nicotinamide; Z32410126; F1077-0095

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1228702
TTD Drug ID: DM10A9S

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Monoamine oxidase type A (MAO-A)	DTT	MAOA	7.207	8.159	9.043	7.711

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monoamine oxidase type A (MAO-A)	DTT	MAOA	8.14E-01	0.05	0.1

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64.