Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM19I62)

• Drug Name: 7-Phloroethol Drug Info
• Synonyms: 7-Phloroeckol; 7-Phloroethol; UNII-97GCC12YF0; CHEMBL456228; 97GCC12YF0; CHEBI:65790; 4-(3,5-dihydroxyphenoxy)-8-(2,4,6-trihydroxyphenoxy)oxanthrene-1,3,6-triol; 1-(3',5'-Dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin; 7-Phloroglucinoleckol; SCHEMBL10271928; BDBM50276826; 4-(3,5-Dihydroxyphenoxy)-8-(2,4,6-trihydroxyphenoxy)dibenzo(b,E)(1,4)dioxin-1,3,6-triol; [(2,4,9-Trihydroxydibenzo-p-dioxin-1,7-diyl)dioxydibenzene]-2',3,4',5,6'-pentol; Dibenzo(b,E)(1,4)dioxin-1,3,6-triol, 4-(3,

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 10480940
  ChEBI ID: CHEBI:65790
  CAS Number: CAS 662165-35-7
  TTD Drug ID: DM19I62

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Beta-secretase (BACE)	TT8JRS7	NOUNIPROTAC	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Beta-secretase (BACE)	DTT	BACE	5.928	4.638	6.443	5.3

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Beta-secretase (BACE)	DTT	NO-GeName	6.98E-04	1.03	2.84

References

• [1] Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3211-5.