Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1CLKO)

Drug Name

ASKP-1240 Drug Info

Synonyms

Anti-CD40 mAb (organ transplant rejection/autoimmune disease), Kirin/Astellas; Anti-CD40 mAb (organ transplant rejection/autoimmune disease), Kyowa Hakko Kirin/Astellas; 4D11

Indication

Disease Entry	ICD 11	Status	REF
Transplant rejection	NE84	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DM1CLKO

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
CD40L receptor (CD40)	TTN6Y9A	TNR5_HUMAN	Not Available	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
CD40L receptor (CD40)	DTT	CD40	4.629	4.991	5.53	3.385

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Transplant rejection

ICD Disease Classification

NE84

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
CD40L receptor (CD40)	DTT	CD40	4.61E-01	0.56	0.5

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT01585233) A Multiple Dose Escalation Study of ASKP1240 in Subjects With Moderate to Severe Plaque Psoriasis. U.S. National Institutes of Health.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1874).