Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1MRFW)

Drug Name

NSC-119911 Drug Info

Synonyms

NSC119911; CHEMBL258670; CHEMBL3260988; NSC-119911; MLS-0111616.0001; AC1OBGP2; AC1NTI1U; AC1NS1JN; SCHEMBL2846330; SCHEMBL2846323; CHEMBL502775; (9Z)-9-(3,3-dihydroxyprop-2-enylidene)-5,6-dihydroxyxanthene-3,4-dione; ZINC3954334; BDBM50011357; NSC158917; NCI119911; CCG-36604; BDBM50373125; NSC-158917; 9-(3,3-dihydroxyprop-2-enylidene)-5,6-dihydroxyxanthene-3,4-dione; (E)-3-(3,4,5-trihydroxy-6-oxo-xanthen-9-yl)prop-2-enoic acid; 2-Propenoic acid, 3-(4,5,6-trihydroxy-3-oxo-3H-xanthen-9-yl)-, (2E)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 54686376
TTD Drug ID: DM1MRFW

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Heat shock protein 70 (HSP70)	TTHYBIX	HS71A_HUMAN; HS71B_HUMAN	Inhibitor	[1]
Lipopolysaccharide-associated protein 1 (HSPA8)	TTMQL3K	HSP7C_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Heat shock protein 70 (HSP70)	DTT	HSPA1A; HSPA1B	1.03E-20	0.32	1.2

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.