Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1Q36W)

Drug Name

1-(1-Benzo[b]thiophen-2-yl-cyclopentyl)-azepane Drug Info

Synonyms

CHEMBL18025; AC1LCXWM; 1-(1-Benzo[b]thiophen-2-yl-cyclopentyl)-azepane; XZXHOFZYYWGLCJ-UHFFFAOYSA-N; BDBM50040198; 1-[1-(1-Benzothien-2-yl)cyclopentyl]azepane #; 1-[1-(1-benzothiophen-2-yl)cyclopentyl]azepane; Thionaphthene, 2-[1-(1-azacycloheptyl)cyclopentyl]-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 608630
TTD Drug ID: DM1Q36W

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine transporter (DAT)	DTT	SLC6A3	4	2.609	5.233	3.7

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine transporter (DAT)	DTT	SLC6A3	1.08E-03	-3.08	-1.99

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-bin... J Med Chem. 1993 Apr 30;36(9):1188-93.