Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1SB94)

Drug Name
Tiprelestat Drug Info
Synonyms Elafin; Recombinant leukocyte elastase/proteinase-3 inhibitor (iv, inflammation), Proteo Biotech
Indication
Disease Entry ICD 11 Status REF
Myocardial infarction BA41-BA43 Phase 2 [1]
Cross-matching ID
PubChem CID
44201346
CAS Number
CAS 820211-82-3
TTD Drug ID
DM1SB94

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Leukocyte proteinase-3 (PRTN3) TT5MLC4 PRTN3_HUMAN Modulator [2]
Neutrophil elastase (NE) TTPLTSQ ELNE_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Neutrophil elastase (NE) DTT ELANE 2.379 2.036 1.379 2.945
Leukocyte proteinase-3 (PRTN3) DTT PRTN3 5.558 2.828 4.138 5.236
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Myocardial infarction
ICD Disease Classification BA41-BA43
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Neutrophil elastase (NE) DTT ELANE 2.35E-01 -0.55 -0.82
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021706)
2 Company report (Proteo Biotech AG)