Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1T6ZN)

Drug Name

Pacritinib Drug Info

Synonyms

JAK inhibitor (alone or in combination)s

Indication

Disease Entry	ICD 11	Status	REF
Myelofibrosis	2A20.2	Approved	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fms-like tyrosine kinase 3 (FLT-3)	TTGJCWZ	FLT3_HUMAN	Modulator	[2]
Janus kinase 3 (JAK-3)	TTT7PJU	JAK3_HUMAN	Modulator	[1]
Janus kinase 2 (JAK-2)	TTRMX3V	JAK2_HUMAN	Modulator	[3]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Janus kinase 2 (JAK-2)	DTT	JAK2	4.957	5.257	4.986	4.784

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Myelofibrosis

ICD Disease Classification

2A20.2

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Fms-like tyrosine kinase 3 (FLT-3)	DTT	FLT3	2.11E-01	-0.05	-0.16

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 208712.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1807).
3	National Cancer Institute Drug Dictionary (drug id 609888).