Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1XJBE)

Drug Name

OLPADRONIC ACID SODIUM SALT Drug Info

Synonyms

Dimethyl-APD; IG-8801; Olpadronic acid sodium salt; 3-(Dimethylamino)-1-hydroxypropylidene-1,1-diphosphonic acid monosodium salt

Indication

Disease Entry	ICD 11	Status	REF
Bone resorption	FC0Z	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Geranyltranstransferase (FDPS)	TTIKWV4	FPPS_HUMAN	Modulator	[1]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Bone resorption

ICD Disease Classification

FC0Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Geranyltranstransferase (FDPS)	DTT	FDPS	7.06E-03	-0.73	-2.57

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo. Biochem Biophys Res Commun. 1999 Feb 16;255(2):491-4.