Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1XY7C)

Drug Name

(4-benzhydrylpiperazin-1-yl)(cyclohexyl)methanone Drug Info

Synonyms

CHEMBL1088730; AC1LKN75; (4-benzhydrylpiperazin-1-yl)(cyclohexyl)methanone; Oprea1_813517; Oprea1_627428; AC1Q5F91; MolPort-001-543-551; STK413456; BDBM50312578; ZINC19834645; AKOS003287837; MCULE-5141193554; ST50927985; 4-(diphenylmethyl)piperazinyl cyclohexyl ketone; (4-benzhydrylpiperazin-1-yl)-cyclohexylmethanone; 1-cyclohexanecarbonyl-4-(diphenylmethyl)piperazine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 994313
TTD Drug ID: DM1XY7C

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cannabinoid receptor 1 (CB1)	TT6OEDT	CNR1_HUMAN	Inhibitor	[1]
Cannabinoid receptor 2 (CB2)	TTMSFAW	CNR2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Cannabinoid receptor 2 (CB2)	DTT	CNR2	7.037	6.733	6.944	7.163
Cannabinoid receptor 1 (CB1)	DTT	CNR1	2.907	4.667	2.982	3.678

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cannabinoid receptor 1 (CB1)	DTT	CNR1	5.59E-02	-0.22	-0.45
Cannabinoid receptor 1 (CB1)	DTT	CNR1	7.68E-01	-0.06	-0.46

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach. Eur J Med Chem. 2010 Mar;45(3):1133-9.