Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM20LIM)

Drug Name
Bremelanotide Drug Info
Synonyms Bremelanotide (USAN/INN); PT-141; Rekynda
Indication
Disease Entry ICD 11 Status REF
Hypoactive sexual desire dysfunction HA00 Approved [1]
Erectile dysfunction HA01.1 Phase 3 [2]
Cross-matching ID
PubChem CID
9941379
CAS Number
CAS 189691-06-3
TTD Drug ID
DM20LIM
ACDINA Drug ID
D00888

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Melanocortin receptor 1 (MC1R) TT0MV2T MSHR_HUMAN Agonist [1]
Melanocortin receptor 4 (MC4R) TTD0CIQ MC4R_HUMAN Agonist [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Melanocortin receptor 4 (MC4R) DTT MC4R 5.904 5.009 4.548 4.597
Melanocortin receptor 1 (MC1R) DTT MC1R 5.907 5.989 5.883 6.877
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Hypoactive sexual desire dysfunction
ICD Disease Classification HA00
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Melanocortin receptor 4 (MC4R) DTT MC4R 5.64E-01 -0.04 -0.18
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
2 Designing drugs for the treatment of female sexual dysfunction. Drug Discov Today. 2007 Sep;12(17-18):757-66.