Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM21K0E)

• Drug Name: ISOTETRANDRINE Drug Info
• Synonyms: O-Methylberbamine; O,O'-Dimethylobamegine; Isosinomenine A; NSC 97338; O,O'-Dimethylstepholine; Isosinomenin A; CHEBI:80898; 1-ISOTETRANDRINE; 6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman; Hanfangchin A; CCRIS 6540; 6,6& ,7,12-Tetramethoxy-2,2& C38H42N2O6; (+)-Isotetrandrine; tetramethoxy(dimethyl)[ ]; Phaeanthin; O,O-Dimethylobamegine; O,O-Dimethylstepholine; AC1L1KBN; AC1Q58ES; (1.beta.)-6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman; SCHEMBL209832; CHEMBL367260; WVTKBKWTSCPRNU-UHFFFAOYSA-N

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 457825
  CAS Number: CAS 477-57-6
  TTD Drug ID: DM21K0E

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine transporter (DAT)	DTT	SLC6A3	4	2.609	5.233	3.7

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine transporter (DAT)	DTT	SLC6A3	1.08E-03	-3.08	-1.99

References

• [1] Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84.