General Information of Drug (ID: DM2FTIC)

Drug Name
2-NAP Drug Info
Synonyms N-(2-Naphthylsulfonyl)-L-aspartic acid 2-phenylethylamide sodium salt
Indication
Disease Entry ICD 11 Status REF
Gastrointestinal disease DE2Z Investigative [1]
Cross-matching ID
PubChem CID
9867157
CAS Number
CAS 141577-40-4
TTD Drug ID
DM2FTIC

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cholecystokinin receptor type A (CCKAR) TTCG0AL CCKAR_HUMAN Antagonist [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Cholecystokinin receptor type A (CCKAR) DTT CCKAR 3.907 4.133 2.858 3.892
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Gastrointestinal disease
ICD Disease Classification DE2Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Cholecystokinin receptor type A (CCKAR) DTT CCKAR 9.99E-01 -0.03 -0.2
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Unexpected relationship between plasma protein binding and the pharmacodynamics of 2-NAP, a CCK1-receptor antagonist. Br J Clin Pharmacol. 2007 May;63(5):618-22.