Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM2HGCB)

Drug Name

VU10010 Drug Info

Synonyms

633283-39-3; VU 10010; 3-amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide; VU-10010; CHEMBL1212994; VU10010; 3-amino-N-(4-chlorobenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide; FPRULFHDSFKYBV-UHFFFAOYSA-N; 2fLI; 2-Fly; f-LIGRLO-NH2; AC1LEM0C; 2-fAP; 2-f-LIGRLO-NH2; MLS002474501; cid_714286; CTK5B8654; DTXSID30351931; MolPort-002-722-568; HMS3431D09; ZINC109066; STL227650; BDBM50323691; AKOS000282930; MCULE-8947006791; NCGC00378784-01; KB-81468; SMR001398666; RT-016241; B7285

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 714286
CAS Number: CAS 633283-39-3
TTD Drug ID: DM2HGCB

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M4 (CHRM4)	TTQ3JTF	ACM4_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Muscarinic acetylcholine receptor M4 (CHRM4)	DTT	CHRM4	6.227	5.863	5.776	5.567

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Muscarinic acetylcholine receptor M4 (CHRM4)	DTT	CHRM4	1.93E-01	-0.08	-0.27
Muscarinic acetylcholine receptor M4 (CHRM4)	DTT	CHRM4	1.62E-01	-0.11	-0.63

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat Chem Biol. 2008 Jan;4(1):42-50.