Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM2L7TH)

• Drug Name: GSK1521498 Drug Info
• Synonyms: GSK-1521498; GSK-1521498B

Indication

Disease Entry	ICD 11	Status	REF
Obesity	5B81	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 24737629
  CAS Number: CAS 1007573-18-3
  TTD Drug ID: DM2L7TH

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Opioid receptor mu (MOP)	TTKWM86	OPRM_HUMAN	Agonist	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Opioid receptor mu (MOP)	DTT	OPRM1	4.548	5.062	4.652	4.776

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Obesity
• ICD Disease Classification: 5B81

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Opioid receptor mu (MOP)	DTT	OPRM1	5.94E-01	-0.02	-0.17

References

• [1] Clinical pipeline report, company report or official report of GlaxoSmithKline (2011).
• [2] Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).