Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM2MJ9F)

Drug Name

6-bromo-N-m-tolylquinazolin-4-amine Drug Info

Synonyms

CHEMBL1081537; 6-bromo-N-m-tolylquinazolin-4-amine; AC1LEZQQ; Oprea1_147022; Neuro1_000540; MLS000684595; SCHEMBL4349199; MolPort-000-660-263; HMS3380E09; HMS2596L23; ZINC122234; BDBM50311883; AKOS002348862; MCULE-2560701920; SMR000268469; ST50477342; EU-0043981; 6-bromo-N-(3-methylphenyl)quinazolin-4-amine; 6-bromo-N-(3-methylphenyl)-4-quinazolinamine; (6-bromoquinazolin-4-yl)(3-methylphenyl)amine; SR-01000485095

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 720633
TTD Drug ID: DM2MJ9F

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 5 (mGluR5)	TTHS256	GRM5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Metabotropic glutamate receptor 5 (mGluR5)	DTT	GRM5	3.621	1.888	3.567	4.318

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Metabotropic glutamate receptor 5 (mGluR5)	DTT	GRM5	9.81E-07	-0.26	-0.54

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6.