Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM2UMGE)

Drug Name

Ad5-TRAIL Drug Info

Synonyms

Ad5-TRAIL adenoviral gene therapy (prostate cancer), University of Iowa

Indication

Disease Entry	ICD 11	Status	REF
Prostate cancer	2C82.0	Phase 1	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TNF related apoptosis inducing ligand (TNFSF10)	TTA5MS9	TNF10_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
TNF related apoptosis inducing ligand (TNFSF10)	DTT	TNFSF10	5.928	7.18	8.754	8.143

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Prostate cancer

ICD Disease Classification

2C82.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
TNF related apoptosis inducing ligand (TNFSF10)	DTT	TNFSF10	4.40E-01	-0.16	-0.18

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Phase I trial of Ad5-TRAIL-mediated gene transfer in men with locally-confined prostate cancer prior to planned radical prostatectomy. The Journal of Urology. 04/2008; 179(4):396-396.
2	Enhancement of Ad5-TRAIL cytotoxicity against renal cell carcinoma with histone deacetylase inhibitors. Cancer Gene Ther. 2006 Jun;13(6):628-32.