Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM2VO97)

Drug Name

RK-023 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Alopecia	ED70	Phase 2	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Chloride channel protein 2 (CLC-2)	TT30NW6	CLCN2_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Chloride channel protein 2 (CLC-2)	DTT	CLCN2	2.868	6.238	5.57	4.129

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification

14 Disease of the skin

Disease Class

ICD-11: EA90 Psoriasis

The Studied Tissue

Skin from scalp

The Studied Disease

Alopecia [ICD-11:EA90]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Chloride channel protein 2 (CLC-2)	DTT	CLCN2	8.78E-02	-0.01	-0.06

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030641)
2	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.