Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM31VLA)

Drug Name

6-Iodo-2-piperazin-1-yl-quinoline Drug Info

Synonyms

6-Iodo-2-piperazin-1-yl-quinoline; 296759-25-6; 6-Iodo-2-(piperazin-1-yl)quinoline; CHEMBL38466; 2-Piperazino-6-iodoquinoline; SCHEMBL6364907; C13H14IN3; DTXSID00476408; ZINC2527444; 3556AJ; BDBM50090210; AKOS024260375; NE63975; AB19831; ACM296759256; AJ-83657; AX8289444; DB-068143

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 12044728
CAS Number: CAS 296759-25-6
TTD Drug ID: DM31VLA

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Serotonin transporter (SERT)	DTT	SLC6A4	6.278	5.469	6.075	6.966

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Serotonin transporter (SERT)	DTT	SLC6A4	8.76E-01	7.18E-05	6.19E-04

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1559-62.