Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM34IX5)

Drug Name

2,2-Dimethoxy-1,2-diphenyl-ethanone Drug Info

Synonyms

24650-42-8; 2,2-Dimethoxy-2-phenylacetophenone; 2,2-Dimethoxy-1,2-diphenylethanone; Benzil dimethyl ketal; Kayacure BDMK; Irgacure 651; Ethanone, 2,2-dimethoxy-1,2-diphenyl-; Lucirin BDK; Photomer 51; Esacure KB 1; Irgacure 641; Irgacure 621; Irgacure I 651; Irgacure E 651; Benzil Dimethylketal; Irgacure 951; Benzil mono(dimethyl ketal); 2,2-Dimethoxy-1,2-diphenylethan-1-one; Benzil mono(dimethyl acetal); Benzil dimethyl acetal; alpha,alpha-Dimethoxy-alpha-phenylacetophenone; KB 1; 2,2-Dimethoxy-1,2-diphenyl-ethanone

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 90571
CAS Number: CAS 24650-42-8
TTD Drug ID: DM34IX5

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Liver carboxylesterase (CES1)	TTMF541	EST1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Liver carboxylesterase (CES1)	DTT	CES1	12.04	6.525	5.311	5.909

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Liver carboxylesterase (CES1)	DTT	CES1	3.82E-08	1.86	1.9

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15.