Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM360VU)

Drug Name

L-652731 Drug Info

Synonyms

CHEMBL297624; L-652731; AC1OCET6; SCHEMBL7018011; BDBM50366241; U-80271; (2R,5R)-2,5-bis(3,4,5-trimethoxyphenyl)oxolane; ([trans-2,5-bis(3,4,5-trimethoxyphenyl)tetrahydrofuran])

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6917920
TTD Drug ID: DM360VU

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Platelet-activating factor receptor (PTAFR)	TTQL5VC	PTAFR_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Platelet-activating factor receptor (PTAFR)	DTT	PTAFR	6.345	5.947	6.084	6.253

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Platelet-activating factor receptor (PTAFR)	DTT	PTAFR	3.53E-02	0.33	2.12

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,... J Med Chem. 1992 Sep 18;35(19):3474-82.